Month: April 2023

4-Aminoquinolines Bearing a 1,3-Benzodioxole Moiety: Synthesis and Biological Evaluation as Potential Antifungal Agents was written by Yang, Rui;Li, Zhuolin;Xie, Jialing;Liu, Jianchuan;Qin, Tianhong;Liu, Junda;Du, Haiying;Ye, Haoyun. And the article was included in Chemistry & Biodiversity in 2021.Electric Literature of C9H9NO3 This article mentions the following:

In search of new environmentally friendly and effective antifungal agents, a series of 4-aminoquinolines bearing a 1,3-benzodioxole moiety were prepared and their structures were fully elucidated by spectroscopic analyses. The antifungal activities of all the target compounds against five phytopathogenic fungi were evaluated in vitro. The results revealed that most of the newly synthesized compounds exhibited obvious inhibitory activities at the concentration of 50μg/mL. Among them, compound I displayed more promising antifungal potency with EC₅₀ values of 10.3 and 14.0μg/mL against C. lunata and A. alternate, resp. Particularly, the EC₅₀ value of I against C. lunata was 7.3-fold as potent as the standard azoxystrobin. There were some significant morphol. alterations in the mycelia of C. lunata when treated with I at 50μg/mL. Addnl., the preliminary structure-activity relationships (SARs) were also discussed. Thus, this study suggests that 4-aminoquinolines bearing a 1,3-benzodioxole moiety are interesting scaffolds for the development of novel antifungal agents. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Electric Literature of C9H9NO3).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C9H9NO3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Copper complexes bearing an NHC-calixarene unit: synthesis and application in click chemistry was written by Ourri, Benjamin;Tillement, Olivier;Tu, Tao;Jeanneau, Erwann;Darbost, Ulrich;Bonnamour, Isabelle. And the article was included in New Journal of Chemistry in 2016.Formula: C4H7BrO2 This article mentions the following:

The synthesis of N-heterocyclic carbene (NHC) copper complexes supported by calix[4]arene is reported. Mono-substituted calix[4]arene was prepared through conventional procedures, followed by the attachment of an imidazolyl group to create the precursor of NHC ligands. Alkylation with two alkyl bromides followed by metalation resulted in fully characterized original complexes. The x-ray structure showed an “out” conformation for copper. The catalytic activity of the complexes was studied in click chem., and revealed good performances. In particular, three new triazoles were synthesized in high yields, under solvent-free conditions and a fast reaction time. The newly synthesized chiral complex was tested in the kinetic resolution of racemic azide. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Formula: C4H7BrO2).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C4H7BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem