Month: December 2022

Polymer supported arene-catalyzed lithiation reactions was written by Gomez, Cecilia;Ruiz, Sonia;Yus, Miguel. And the article was included in Tetrahedron in 1999.Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane This article mentions the following:

The reaction of functionalized chlorinated materials with an excess of lithium and a catalytic amount of a naphthalene (P_N) or biphenyl (P_B) supported polymer (easily prepared by radical copolymerization of 2-vinylnaphthalene or 4-vinylbiphenyl with vinylbenzene and divinylbenzene) in THF and electrophiles [Me₃SiCl, ⁱPrCHO, PhCHO, Et₂CO, (CH₂)₄CO, (CH₂)₅CO, (c-C₃H₅)₂CO, iPr₂CO, PhCOMe, PhCH=NPh] at -78 or -50°C leads, after hydrolysis with water, to the expected functionalized products. Such polymeric reagents were 2-ethenylnaphthalene polymer with ethenylbenzene and diethenylbenzene and 4-ethenyl-1,1′-biphenyl polymer with ethenylbenzene and diethenylbenzene. The polymeric catalyst is quant. recovered and can reused several times without any loss of activity. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

One-pot α-bromoacetalization of carbonyl compounds was written by Visweswariah, Sandhya;Prakash, G.;Bhushan, Vidya;Chandrasekaran, S.. And the article was included in Synthesis in 1982.Safety of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

Alkanones and cycloalkanones were treated with HOCH₂CH₂OH and PhN⁺Me₃ Br₃^– to yield α-bromo ketone ethylene ketals. Thus, PhN⁺Me₃ Br₃^– was added to Me₂CO, HOCH₂CH₂OH, and THF, and the mixture was stirred ≥ 20 h at room temperature to give bromoacetone ethylene ketal. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Safety of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A study of deketalization of rigid β-aminoketones was written by Kim, Jack C.;Lee, Yong Tae;Yoon, Ung Chan;Cho, In Seop;Moon, Sung Hwan;Han, Sun Hong. And the article was included in Taehan Hwahakhoe Chi in 1988.SDS of cas: 3418-21-1 This article mentions the following:

The causes of failure in the deketalization of rigid β-aminoketals were sep. investigated by examining the deketalization of ketals I (R = NH₂, N⁺Me₃, NHAc), and by examining the deketalization of non-rigid β-aminoketal 2-amino-1-ethylenedioxyacetophenone (II) and non-rigid aliphatic acetals R¹CH(OMe)₂ (III, R¹ = NMe₂, CH₂NH₂). While I (R = NH₂, N⁺Me₃) were not hydrolyzed in the various acidic conditions, I (R = NHAc) was easily deketalized. These results indicate the importance of electrostatic repulsion in the dicationic intermediates as a factor in the failure of deketalization. The easy deketalization of compounds II and III indicate that the structural characters of rigid β-aminoketals are also important factors in the hydrolysis of β-aminoketals. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1SDS of cas: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and structural characterization of lower rim halogenated pyrogallol[4]arenes: bi-layers and hexameric nano-capsules was written by Dalgarno, Scott J.;Power, Nicholas P.;Antesberger, Jochen;McKinlay, Robert M.;Atwood, Jerry L.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2006.Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane This article mentions the following:

Two lower rim halogenated pyrogallol[4]arenes have been synthesized and structurally characterized as either bi-layer or hexameric nano-capsule motifs depending upon chain length and functionalization. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and application of poly(diallyldimethylammonium tribromide) as a novel polymeric brominating agent was written by Hossein, Mahdavi;Zahra, Kachoei. And the article was included in Chinese Journal of Chemistry in 2010.Product Details of 3418-21-1 This article mentions the following:

In this study, the synthesis and applications of a new supported tribromide reagent is reported. This supported tribromide is used in α-bromoacetalization of ketones, bromination of alkenes and regioselective bromination of activated aromatic compounds This method is mild and no Br₂ and HBr were used. Other advantages of this reagent are stability, high efficiency, simple filterability and reusability. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Product Details of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Anodic functionalization of alkenes in alcoholic medium in the presence of metal halides was written by Elinson, M. N.;Makhova, I. V.;Nikishin, G. I.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1990.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

The electrolysis of arylolefins in presence of alkali metal bromides led to formation of 1-aryl-2-bromo-ketals in alcs. The efficiency of the electrolysis was 60-90%. The 2-methyl-1-phenyl-1-propene formed 1-bromo-2-methyl-1-phenyl-1-propene with yield of 80%. Arylolefins without benzidine H atoms formed 1-aryl-1-alkoxy-2-bromoalkanes. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Dienediolates of unsaturated carboxylic acids in synthesis. Aldehydes and ketones from alkyl halides, by ozonolysis of β,γ-unsaturated α-alkyl carboxylic acids. The role of a tertiary amine in the cleavage of ozonides was written by Aurell, Maria Jose;Ceita, Luisa;Mestres, Ramon;Tortajada, Amparo. And the article was included in Tetrahedron in 1997.Formula: C7H13ClO2 This article mentions the following:

A convenient two-step procedure for a two carbon homologative conversion of alkyl halides into aldehydes and Me ketones by α-alkylation of unsaturated carboxylic acids, followed by ozonolysis is developed and applied to the synthesis of ω-chloro aldehydes. Triethylamine is superior to di-Me sulfide or triphenylphosphine for cleavage of the ozonides, except when aldol condensation side reactions require use of protic solvents and iodide salts. Cleavage of the ozonides by triethylamine is shown to occur mainly through a reductive process. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Formula: C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Formula: C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Enantioselective synthesis of quinolizidines and indolizidines via a catalytic asymmetric hydrogenation cascade was written by Rueping, Magnus;Hubener, Lukas. And the article was included in Synlett in 2011.Recommanded Product: 3418-21-1 This article mentions the following:

A catalytic enantioselective synthesis of a new class of quinolizidines and indolizidines is presented. An asym. Bronsted acid catalyzed hydrogenation cascade as well as a sequential Bronsted acid/metal catalyzed hydrogenation protocol of 2-substituted quinolines yields benzofused quinolizidines and indolizidines in good yields with high diastereo- and enantioselectivities. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Heme Oxygenase Inhibition by 1-Aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl)ethanones and Their Derivatives was written by Roman, Gheorghe;Vlahakis, Jason Z.;Vukomanovic, Dragic;Nakatsu, Kanji;Szarek, Walter A.. And the article was included in ChemMedChem in 2010.Related Products of 3418-21-1 This article mentions the following:

Previous studies by our research group have been concerned with the design of selective inhibitors of heme oxygenases (HO-1 and HO-2). The majority of these were based on a four-carbon linkage of an azole, usually an imidazole, and an aromatic moiety. In the present study, we designed and synthesized a series of inhibition candidates containing a shorter linkage between these groups, specifically, a series of 1-aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl)ethanones and their derivatives As regards HO-1 inhibition, the aromatic moieties yielding best results were found to be halogen-substituted residues such as 3-bromophenyl, 4-bromophenyl, and 3,4-dichlorophenyl, or hydrocarbon residues such as 2-naphthyl, 4-biphenyl, 4-benzylphenyl, and 4-(2-phenethyl)phenyl. Among the imidazole-ketones, five (36-39, and 44) were found to be very potent (IC₅₀<5 μM) toward both isoenzymes. Relative to the imidazole-ketones, the series of corresponding triazole-ketones showed four compounds (54, 55, 61, and 62) having a selectivity index >50 in favor of HO-1. In the case of the azole-dioxolanes, two of them (80 and 85), each possessing a 2-naphthyl moiety, were found to be particularly potent and selective HO-1 inhibitors. Three non-carbonyl analogs (87, 89, and 91) of 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethanone were found to be good inhibitors of HO-1. For the first time in our studies, two azole-based inhibitors (37 and 39) were found to exhibit a modest selectivity index in favor of HO-2. The present study has revealed addnl. candidates based on inhibition of heme oxygenases for potentially useful pharmacol. and therapeutic applications. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Related Products of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem