Month: December 2022

A convenient procedure for the synthesis of acetals from α-halo ketones was written by Carlson, Rolf;Gautun, Hanna;Westerlund, Andreas. And the article was included in Advanced Synthesis & Catalysis in 2002.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

A study for determining the scope and limitations of a procedure for synthesizing ethylene acetals from haloketones is presented. The method uses 1,2-bis(trimethylsilyloxy)ethane, BTSE, as reagent and Nafion-TMS as catalyst. Two procedures have been tested: (A) stoichiometric amounts of the haloketone and BTSE and a catalytic amount of Nafion-TMS were heated to reflux in chloroform solution, and (B) stoichiometric amounts of the reactants and a catalytic amount of Nafion-TMS were heated to 90-100°C in the absence of solvent. The following ketones have been tested: 2-bromo-1-phenyl-1-ethanone, 2-bromo-cyclopentenone, 3-bromo-3-methyl-2-butanone, 3-chloro-3-methyl-2-butanone, 1-bromo-3,3-dimethyl-2-butanone, 1-chloro-3,3-dimethyl-2-butanone, 2-bromocyclohexanone, 2-chloro-1-cyclohexyl-1-ethanone, 1,1-dibromo-3,3-dimethyl-2-butanone, 1,3-dibromo-3-methyl-2-butanone, 1,3-dibromo-2-butanone, 1,3-dibromo-2-propanone, 2-chloro-1-phenyl-1-ethanone, and endo-2-bromocamphor. Yields were in the range 57-100% with the exceptions of endo-2-bromocamphor which afforded <10% yield and the dibromoketones 1,1-dibromo-3,3-dimethyl-2-butanone and 1,3-dibromo-3-methyl-2-butanone for which the method failed. Factors determining the scope and limitations are briefly discussed. Full exptl. details and spectroscopic data of the acetals are given. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

One-pot synthesis of some new α-bromoketals and acetals via 1,8-diazabicyclo[5.4.0] undec-7-ene-hydrobromide-perbromide was written by Hajizadeh, Neda;Bakavoli, Mehdi;Pordel, Mehdi. And the article was included in Iranian Journal of Chemistry & Chemical Engineering in 2017.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

α-Bromoketals and acetals are important synthetic precursors in organic synthesis. In this work, some new α-bromoketals are synthesized by the reaction of aryl Me ketones with diols in the presence of 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) hydrobromide-perbromide in good isolated yields. The latter compound converts aldehydes to acetals and serves as a new and efficient reagent for the synthesis of acetals. Comparative studies of the preparation of α-bromoketal and acetals using some reported methods vs. the present method show that DBUH-Br₃ is one of the most efficient reagents for the preparation of these compounds Conversion of carbonyl compounds to corresponding α-bromoketals and acetals in the presence of DBUH-Br₃ under microwave irradiation is also described. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Electrochemical oxidation of conjugated arylolefins to α-bromoketals was written by Nikishin, Gennady I.;Elinson, Michail N.;Makhova, Irina V.. And the article was included in Tetrahedron Letters in 1988.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

Conjugated arylolefins electrolyzed in alcs. in the presence of alkali metal bromides were transformed into α-bromoketals. Thus RC₆H₄CH:CHR¹ (R = R¹ = H; R = p-Me, R = H; R = m-Cl, R¹ = H; R = H, R¹ = Me; R = p-MeO, R¹ = Me) was electrolyzed in MeOH containing NaBr in an undivided cell with a Pt anode, Cu-Zn (60:40) cathode at 60° under constant c.d. 220 mA/cm². RC₆H₄C(OMe)₂CHR¹Br was formed. Electrolysis of C₆H₅CH:CH₂ in ethylene glycol gave cyclic α-bromoketal. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and reactivity of some α-bromoketals was written by Kahlert, E. U.;Zymalkowski, F.. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1975.SDS of cas: 3418-21-1 This article mentions the following:

Ketals I [X = (CH2)n, n = 1-3; OCH2] and II (R = H, Me, Et), prepared by reaction of the bromo ketone with ethylene glycol, were treated with secondary amines to give α,β-unsaturated ketals. If elimination of HBr was impossible, Br was substituted by amine. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1SDS of cas: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Polymer supported naphthalene-catalyzed lithiation reactions was written by Gomez, Cecilia;Ruiz, Sonia;Yus, Miguel. And the article was included in Tetrahedron Letters in 1998.Application of 118336-86-0 This article mentions the following:

The reaction of functionalized mono- or dichlorinated materials with an excess of lithium and a catalytic amount of a naphthalene-containing polymer (P-152, easily prepared by radical copolymerization of 2-vinylnaphthalene, styrene and divinylbenzene) in THF either in the presence (Barbier-type conditions) or absence of different electrophiles [Me₃SiCl, BuCHO, iso-BuCHO, PhCHO, Et₂CO, c(C₃H₅)₂CO, iso-Pr₂CO, (CH₂)₄CO, (CH₂)₅CO, PhCOMe, PhCH:NPh] leads, after hydrolysis, to the expected products. The catalyst is quant. recovered and can be reused several times without loss of activity. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Application of 118336-86-0).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 118336-86-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation and reactions of N-phenacyl-N-tosylhydroxylamine and -hydrazines was written by Wessig, Pablo;Henning, Hans Georg. And the article was included in Liebigs Annalen der Chemie in 1991.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

O-Alkyl-N-phenacyl-N-tosylhydroxylamines PhCOCH₂NTsOCH₂R (I; Ts = tosyl; R = H, Ph, p-BrC₆H₄) were prepared in two steps from O-alkylhydroxylamines. In the presence of a base, I undergo rearrangement and cleavage to N-tosylphenacylamine and aldehydes RCHO. N-Alkyl-N‘-phenacyl-N,N‘-ditosylhydrazines TsNR¹NR²Ts (R¹ = R² = CH₂COPh or CH₂CO₂Et; R¹ = CH₂COPh, R² = CH₂Ph) were obtained by stepwise treatment of N,N‘-ditosylhydrazine with alkyl halides and phenacyl bromide/potassium tert-butoxide/DMF. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis, characterization, and structures of α-substituted selenenyl-acetophenones was written by Hodage, Ananda S.;Phadnis, Prasad P.;Wadawale, Amey;Priyadarsini, K. I.;Jain, Vimal K.. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2014.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

A series of α-substituted selenenyl acetophenone derivatives of the types, [PhC(OCH₂CH₂O)CH₂Se]₂, [PhC(OCH₂CH₂O)CH₂SeR], (PhCOCH₂Se)₂, and [PhCOCH₂SeR] were prepared These compounds were characterized by elemental analyses, IR and NMR (¹H, ¹³C, ⁷⁷Se) spectroscopy. The structures were established on the basis of the spectroscopic data and confirmed by single crystal x-ray diffraction anal. of bis(1-phenyldioxolonylmethyl) diselenide [monoclinic, space group I2/a, a 11.934 (3), b 10.872 (2), c 15.133 (6) Å, α 90.00, β 95.00, γ 90.00°, V 1955.3 (10) ų, Z 4] and bis(phenacyl) diselenide [orthorhombic, space group Pbca, a 8.705 (3), b 17.760 (9), c 19.517 (7) Å, α 90.00, β 90.00, γ 90.00°, V 3017 (2) ų, Z 8]. The former shows intramol. Se- – -O interaction, while the latter exhibits inter-mol. nonbonding Se- – -O interaction. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Cationic Gold Catalyzes ω-Bromination of Terminal Alkynes and Subsequent Hydroaddition Reactions was written by Leyva-Perez, Antonio;Rubio-Marques, Paula;Al-Deyab, Salem S.;Al-Resayes, Saud I.;Corma, Avelino. And the article was included in ACS Catalysis in 2011.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

Orthogonal σ,π-bisfunctionalization of terminal alkynes can be achieved with a cationic gold complex in catalytic amounts First, the terminal C-H bond is transformed to the corresponding bromoalkyne which is then activated toward nucleophilic attack. This reactivity correlates with the structural nature of isolated gold-alkyne complexes. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and some reactions of indolo[2,1-c]-1,4-oxazinium perchlorates was written by Kibalny, A. V.;Nikolyukin, Yu. A.;Dulenko, V. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1994.Application of 3418-21-1 This article mentions the following:

Title compounds I (R = Me, Et, Pr, CHMe₂, CMe₃, Ph) were prepared by reaction of 1-phenacylskatole with RCO⁺ClO₄^–. I were converted to pyrazine analogs (II; R = alkyl), dimeric compounds (III; R¹ = H, Me), and indolotriazepine IV. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Application of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of diphenacyl telluride and related substances was written by Engman, Lars. And the article was included in Organometallics in 1986.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

(PhCOCH₂)₂Te was prepared for the first time by a mild Na₂S₂O₅ reduction of (PhCOCH₂)₂TeCl₂ in a two-phase system. (RCOCH₂)₂TeCl₂ (R = substituted Ph, 1-, 2-naphthyl, 2-thienyl, 9-anthryl, 2-benzo[b]furanyl), prepared from TeCl₄ and various acetylarom. compounds, were similarly reduced to (RCOCH₂)₂Te. 4-Methoxyphenyl phenacyl telluride and 2-naphthyl phenacyl telluride were similarly prepared The new materials, although unstable, could be handled and characterized without special precautions. Treatment of (PhCOCH₂)₂Te with m-ClC₆H₄C(O)OOH or Na₂S caused decomposition with formation of PhCOMe. Photolysis in dry benzene under N also resulted in formation of PhCOMe. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem