Month: December 2022

One-step synthesis of substituted 2-aryl-2-(bromoalkyl)-1,3-dioxolanes was written by Svoboda, Jiri;Palecek, Jaroslav;Dedek, Vaclav;Mostecky, Jiri. And the article was included in Collection of Czechoslovak Chemical Communications in 1984.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

Bromoketalization of p-RC₆H₄COCHR¹R² (R = H, Me₂CHCH₂, Ph, Me, R¹ = R² = H; R = Me₂CHCH₂, R¹ = H, R² = Me; R = H, R¹ = R² = Me) with ethylene glycol and pyridinium perbromide, dioxane dibromide or PhN⁺Me₃ Br₃^– gave 35-84% I. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A mild and efficient method for one-step α-haloacetalization of acetophenones using 1,3-dihalo-5,5-dimehtylhydantoin in ethylene glycol was written by Zheng, Zu Biao;Li, Zhong Zhou;Han, Bing Bing;He, Zai Ming;Shi, Teng Fei;Cheng, Peng. And the article was included in Tetrahedron Letters in 2015.Recommanded Product: 3418-21-1 This article mentions the following:

A mild and efficient method that could directly prepare α-haloacetal acetophenones from various acetophenones with 1,3-dihalo-5,5-dimehtylhydantoin (DBDMH/DCDMH) and ethylene glycol in good yields without catalysts was reported. The effects of solvents, 1,3-dihalo-5,5-dimehtylhydantoin, and reaction temperature were investigated. Under the optimal condition, most of α-haloacetal acetophenones were obtained in 65-97% yields. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

An eco-friendly and efficient synthesis of benzoylformic acid and methyl benzoylformate from styrene was written by Dai, Zhihong;Peng, Xinhua;Dong, Xiongzi;Shi, Chunjie;Rong, Yuan. And the article was included in Asian Journal of Chemistry in 2012.Recommanded Product: 3418-21-1 This article mentions the following:

The HBr/H₂O₂ system was found to be a highly efficient and green catalytic system for the selective oxidation of styrene. The method was utilized for the synthesis of phenylglyoxalic acid in excellent yields using water as solvent. Subsequent esterification is simple, highly efficient, and inexpensive by using TiO₂/SO₄^2- as catalyst. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

New masked δ-lithio carbonyl compounds: preparation and synthetic applications was written by Gil, Juan F.;Ramon, Diego J.;Yus, Miguel. And the article was included in Tetrahedron in 1993.Recommanded Product: 118336-86-0 This article mentions the following:

The reaction of 2-(4-chlorobutyl)-1,3-dioxolanes I (R = H, Et, Ph; R¹ = Cl) or 2-(4-chlorobutyl)-2-ethyl-1,3-dithiane with an excess of lithium powder and a catalytic amount of naphthalene (8 mol %) in THF at -78° leads to a solution of the corresponding masked lithium δ-enolates, which react with different electrophiles (water, deuterium oxide, carbonyl compounds, carboxylic acid derivatives, dibenzyl disulfide or benzylideneaniline) to yield the expected products, e.g., I [R = H, R¹ = H, D, PhCH(OH), PhCH₂S]. In the presence of a catalytic amount of CuBr.Me₂S, the intermediate I (R = H, R¹ = Li) reacts with cyclohex-2-enone giving the compound I (R = H, R¹ = 3-oxocyclohexyl) through a conjugate addition The deprotection of the dioxolane moiety with 2 N HCl gives the expected functionalized carbonyl compounds In situ generated hydroxy aldehydes react with triethylsilane, allyltrimethylsilane, and trimethylsilyl cyanide to give alcs. [e.g., Et₂CH(CH₂)₅OH], dienic alcs. [e.g., Me₂C:CH(CH₂)₃CH(OH)CH₂CH:CH₂], and cyanooxepanes II (R² = H, R³ = Ph; R² = R³ = Me, Et; R²R³ = (CH₂)₅]. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Recommanded Product: 118336-86-0).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 118336-86-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Optimization of Grignard ring-opening of α-brominated dioxolanes for the preparation of β-hydroxy-protected vinyl ethers by a three-step one-pot procedure was written by Andre, Mathieu;Letribot, Boris;Bayle, Martine;Mounetou, Emmanuelle;Chezal, Jean-Michel. And the article was included in Tetrahedron Letters in 2012.Reference of 3418-21-1 This article mentions the following:

Aliphatic, cyclic, and aromatic benzoate-protected γ-hydroxy enol ethers were prepared from α-brominated dioxolanes by a three-step reaction procedure and a one-pot protocol involving Grignard reagent formation, ring-opening, and final benzoate protection. E.g., addition of Mg to the α-brominated dioxolane (I), followed by treatment with NEt₃, then with benzoyl chloride gave 61% benzoate-protected γ-hydroxy enol ether (II). Addnl., tert-butyldiphenylsilyl, acetate, and 4,4′-dimethoxytrityl were also successfully used as alternative protecting groups. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Reference of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Selective, Orally Active 5-HT_1D Receptor Agonists as Potential Antimigraine Agents was written by MacLeod, Angus M.;Street, Leslie J.;Reeve, Austin;Jelley, Richard A.;Sternfeld, Francine;Beer, Margaret S.;Stanton, Josephine A.;Watt, Alan P.;Rathbone, Denise;Matassa, Victor G.. And the article was included in Journal of Medicinal Chemistry in 1997.Category: dioxole This article mentions the following:

The clin. effective antimigraine drug, sumatriptan, is a serotonin receptor agonist with equal affinity for the 5-HT_1B and 5-HT_1D subtypes. To determine whether a compound selective for the 5-HT_1D subtype would have the same clin. efficacy, but with reduced side effects, a structural exploration of non-selective compounds was carried out to identify features that would provide differential binding affinity for the two receptors. Functionalized piperazinylpropylindoles were shown to have high affinity for 5-HT_1D with binding selectivities greater than 100-fold with respect to 5-HT_1B. The meta-fluorophenethylpiperazine L-775,606 was highlighted as the first orally bioavailable, selective 5-HT_1D agonist. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Category: dioxole).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Vibrational circular dichroism and absolute configuration of 1-substituted indans was written by Fontana, Luca P.;Chandramouly, Tummalapalli;Smith, Howard E.;Polavarapu, Prasad L.. And the article was included in Journal of Organic Chemistry in 1988.Electric Literature of C10H11BrO2 This article mentions the following:

Vibrational CD (VCD) spectra of title compounds (R)- and (S)-I (R = NH₂, R¹ = H), (S)-I (R = Me, R¹ = H), and (R)-I (R = Me, R¹ = D) were measured at 800-1600 cm^-1. The VCD feature associated with the C^*-H bending mode at ∼1350 cm^-1 correlated with their absolute configurations. This correlation agrees with one found for (S)-methyloxirane and (R)-methylthiirane, and reflects the potential importance of VCD measurements in stereochem. anal. of chiral rings systems. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Electric Literature of C10H11BrO2).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C10H11BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Reaction of monohalocarbenes with 2-phenyl-1,3-dioxolane and 4-phenyl-1,3-dioxan was written by Safiev, O. G.;Nazarov, D. V.;Zorin, V. V.;Rakhmankulov, D. L.;Paushkin, Yu. M.. And the article was included in Doklady Akademii Nauk SSSR in 1988.Category: dioxole This article mentions the following:

Carbenes :CHX (X = Cl, Br), generated acoustically from CH₂X₂, solid KOH and PhCH₂NEt₃⁺ Cl^–, inserted into the benzylic C:H bond of the title compounds to give 73-94% 2- and 4-(halomethyl) derivatives, resp. The carbenes were trapped with Me₂C:CMe₂ to give the corresponding halotetramethylcyclopropanes in 87-95% yield. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Category: dioxole).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Acetal and ketal hydrolysis rates in moderately concentrated perchloric acid solutions containing 50% dioxane was written by Kreevoy, Maurice M.. And the article was included in Journal of the American Chemical Society in 1956.Electric Literature of C10H11BrO2 This article mentions the following:

By Kühn’s method (C.A. 35, 1762⁷) were prepared R₁R₂COCH₂CH₂O (I) with R₁ = Ph, R₂ = CH₂CN (II), m. 45.5-46.3°, and R₁ = PhCH₂, R₂ = Me (III), b₁₅ 109°. The acid-catalyzed rates (k) of hydrolysis of CH₂ClC(OEt)₂, of I (R₁ = Ph, R₂ = CH₂Br), and of II and III were determined in a solvent containing 50% dioxane as a function of HClO₄ concentration The ratio of free base to conjugate acid [BH⁺]/[B] for 2-nitro-4-chloroaniline was determined in the same solvent. The quantities log {k/[HClO₄]} and log {[BH⁺]/[B] [HClO₄]} are linear functions of [HClO₄] with approx. equal slopes. Some possible implications of these relations are discussed. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Electric Literature of C10H11BrO2).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Electric Literature of C10H11BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application of poly(vinylphenyltrimethylammonium tribromide) resin as an efficient polymeric brominating agent in the α-bromination and α-bromoacetalization of acetophenones was written by Han, Bingbing;Zheng, Zubiao;Zheng, Dongcheng;Zhang, Lei;Cui, Peng;Shi, Jianjun;Li, Changjiang. And the article was included in Synthetic Communications in 2019.Product Details of 3418-21-1 This article mentions the following:

The applications of a new supported tribromide reagent based on poly(vinylbenzyltrimethylammonium tribromide) resin (Amberlite 717) were reported. This supported tribromide resin was used directly in α-bromination and α-bromoacetalization of acetophenones without any other catalyst under mild conditions. The effects of solvents and the amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, α-bromo such as RC(O)CH₂Br [R = C₆H₅, 2-ClC₆H₄, 4-PhC₆H₄, etc.] and α-bromoacetal such as RC(O(CH₂)₂O)CH₂Br of acetophenones were selectively obtained in excellent yields. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Product Details of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem