Month: October 2022

On October 21, 1999, Hyldtoft, Lene; Poulsen, Carina Storm; Madsen, Robert published an article.Application In Synthesis of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole The title of the article was Zinc-mediated domino elimination-alkylation of methyl 5-iodopentofuranosides: an easy route to unsaturated carbohydrates for transition metal-catalyzed carbocyclizations. And the article contained the following:

5-Iodopentofuranosides are converted with zinc and allyl/propargyl bromide into dienes/enynes which are further used in carbohydrate annulation reactions. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Application In Synthesis of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole

The Article related to cyclitol preparation iodopentofuranoside elimination alkylation zinc catalyst carbocyclization, glycoside iodopentofuranoside elimination alkylation zinc catalyst carbocyclization and other aspects.Application In Synthesis of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On January 31, 2009, Monrad, Rune Nygaard; Fanefjord, Mette; Hansen, Flemming Gundorph; Jensen, N. Michael E.; Madsen, Robert published an article.HPLC of Formula: 38838-06-1 The title of the article was Synthesis of gabosine A and N from ribose by the use of ring-closing metathesis. And the article contained the following:

A concise synthetic route is described for the synthesis of gabosine A and N. The key step uses a zinc-mediated tandem reaction where Me 5-deoxy-5-iodo-2,3-O-isopropylidene-β-D-ribofuranoside is fragmented to give an unsaturated aldehyde which is allylated in the same pot with 3-benzoyloxy-2-methylallyl bromide. The functionalized octa-1,7-diene, thus obtained, is converted into the six-membered gabosine skeleton by ring-closing olefin metathesis. Subsequent protective group manipulations and oxidation gives rise to gabosine N in a total of 8 steps from ribose while the synthesis of gabosine A employs an addnl. step for inverting a secondary hydroxy group. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).HPLC of Formula: 38838-06-1

The Article related to gabosine a n asym preparation, methacrolein benzoyl bromide stereoselective haloacylation, methyl furanoside fragmentation stereoselective allylation ring closing metathesis oxidation and other aspects.HPLC of Formula: 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On August 19, 2005, Gallos, John K.; Stathakis, Christos I.; Kotoulas, Stefanos S.; Koumbis, Alexandros E. published an article.Synthetic Route of 38838-06-1 The title of the article was An Improved Approach to Chiral Cyclopentenone Building Blocks. Total Synthesis of Pentenomycin I and Neplanocin A. And the article contained the following:

An improved approach to enantiomerically pure hydroxylated cyclopentenones is reported here, which involves intramol. nitrone cycloaddition of sugar-derived chiral pent-4-enals and hex-5-en-ones-2 followed by N-O bond cleavage, quaternization of the amine thus produced, and finally oxidative elimination of the amino group. Synthesis of pentenomycin I and neplanocin A is described following this methodol. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Synthetic Route of 38838-06-1

The Article related to oxidative elimination synthesis pentenomycin neplanocin cycloaddition cyclopentenone pentenal, intramol nitrone cycloaddition cyclopentenone pentenal enone bond cleavage quaternization and other aspects.Synthetic Route of 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On February 13, 2013, Tu, Wangyang; Fan, Jiang; Zhang, Haitang; Xu, Guoji; Liu, Zhiwei; Qu, Jian; Yang, Fanglong; Dong, Qing published a patent.Reference of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole The title of the patent was Preparation of triazolopyrimidine derivatives as P2Y12 receptor antagonists. And the patent contained the following:

The title triazolopyrimidine derivatives I [wherein R1 = (un)substituted cycloalkyl or heteroaryl; R2 = (un)substituted alkyl; R3 = halo, (un)substituted alkyl, alkoxy, etc.; R4 = H, alkyl, etc.; or R3 and R4 together to form O or alkenyl; R5 = H, alkyl, hydroxy, etc.; or R4 and R5 together to form cycloalkyl; m = 0-2] or pharmaceutically acceptable salts thereof were prepared as P2Y12 receptor antagonists for treating myocardial infarction, embolism, cerebral ischemia, peripheral vascular disease, angina, or blood coagulation disorders. For example, II was prepared in a multi-step synthesis. In biol. test using P2Y12 receptors, II showed antagonistic activity with IC50 of 1.05 nM. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Reference of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole

The Article related to preparation triazolopyrimidine p2y12 receptor antagonist human, treatment myocardial infarction embolism cerebral ischemia, peripheral vascular disease angina blood coagulation disorder and other aspects.Reference of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On January 31, 2018, Wang, Haribo; Pan, Yang; Tang, Qin; Zou, Wei; Shao, Huawu published an article.Computed Properties of 38838-06-1 The title of the article was Synthesis of N-alkyl substituted iminosugars from D-ribose. And the article contained the following:

An effective and facile method for the synthesis of N-alkylated hydroxylpyrrolidine and hydroxylpiperidine is described. A number of N-alkyl substituted iminosugars were prepared using iodine-induced intramol. cyclization of acyclic alkenylamines as key step. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Computed Properties of 38838-06-1

The Article related to alkylated hydroxylpyrrolidine iminosugar preparation intramol cyclization acyclic alkenylamine, hydroxylpiperidine alkylated iminosugar preparation intramol cyclization acyclic alkenylamine and other aspects.Computed Properties of 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On May 31, 1989, Young, Robert N.; Zamboni, Robert; Gauthier, Jacques Y.; Belley, Michel L. published a patent.Electric Literature of 124038-36-4 The title of the patent was Quinoline diacid derivatives useful as leukotriene antagonists, and their pharmaceutical compositions and use in medicaments. And the patent contained the following:

Title compounds I [R1 = H, halo, alkyl, alkenyl, alkynyl, CF3, SR2, S(O)R2, S(O)2R2, NR3R3, OR3, CO2R3, COR3, C(OH)R3R3, cyano,NO2, N3, (un)substituted Ph, PhCH2, PhCH2CH2, pyridyl; R2 = alkyl, alkenyl, alkynyl, CF3, (un)substituted Ph, PhCH2, PhCH2CH2; R3 = H, R2; R4 = H, halo, NO2, N3, cyano, SR2, NR3R3, OR3, alkyl, COR3; R5 = H, alkyl; Y = CR3:CR3, C:C, CO, NR3CO, CONR3, O, S, NR3, etc.; X1, X2 = complex chains, 1 or both containing C6H4, pyridine, or thiophene nucleus; Q1, Q2 = CO2R3, tetrazole, cyano, CHO, CH2OH, COCH2OH, etc.] are prepared for use as leukotriene antagonists (no data), and thereby as antiasthmatic, antiallergic, antiinflammatory, and cytoprotective agents. Thus, Wittig reaction of Me 2-[3-[2-(methoxycarbonyl)ethylthio]-3-(3-formylphenyl)propyl]benzoate (prepared in 6 steps) with [(7-chloroquinolin-2-yl)methyl]triphenylphosphonium bromide using BuLi in THF, and basic hydrolysis and salification of the product, gave [[[(chloroquinolinyl)ethenyl]phenyl](carboxyethylthio)propyl]benzoic acid di-Na salt II. The experimental process involved the reaction of Methyl 3-(1,3-dioxolan-2-yl)benzoate(cas: 124038-36-4).Electric Literature of 124038-36-4

The Article related to quinoline preparation leukotriene antagonist, antiasthmatic quinoline preparation, antiallergic quinoline preparation, antiinflammatory quinoline preparation, antiulcer quinoline preparation and other aspects.Electric Literature of 124038-36-4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On February 12, 2010, Yadav, J. S.; Reddy, P. Narayana; Reddy, B. V. Subba published an article.COA of Formula: C9H15IO4 The title of the article was Stereoselective total synthesis of (-)-ovalicin. And the article contained the following:

A new synthetic route for epoxyketone I is described, which is a key intermediate in Barton’s synthesis of ovalicin (II), a powerful anti-angiogenetic inhibitor, from com. available D-ribose. The key reactions involved in this synthesis are ring-closing metathesis, Rubottom oxidation and Corey-Chaykovsky epoxidation The subsequent transformations are carried out according to Barton’s strategy to complete the total synthesis of (-)-ovalicin. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).COA of Formula: C9H15IO4

The Article related to ovalicin stereoselective total synthesis ring closing metathesis, rubottom oxidation stereoselective total synthesis ovalicin, corey chaykovsky epoxidation stereoselective total synthesis ovalicin and other aspects.COA of Formula: C9H15IO4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Lerner, Leon M. published an article in 1977, the title of the article was Enantiomeric forms of 9-(5-deoxy-β-erythro-pent-4-enofuranosyl)adenine and a new preparation of 5-deoxy-D-lyxose.Electric Literature of 38838-06-1 And the article contains the following content:

Tosylation of Me 2,3-O-isopropylidene-β-D-ribofuranoside followed by treatment with NaI, deisopropylidenation, benzoylation, and acetolysis gave I. Condensation of I with 6-benzamidochloromercuripurine followed by treatment with 1,5-diazabicyclo[5.4.0]undec-5-ene and subsequent deblocking gave II. The enantiomeric III was similarly prepared from Me 2,3-O-isopropylidene-α-D-lyxopyranoside (IV). Oxidation of Me 2,3-O-isopropylidene-α-D-mannofuranoside with NaIO4 followed by reduction with NaBH4 to give IV and subsequent acid hydrolysis gave D-lyxose. Tosylation of IV followed by reductive cleavage and subsequent hydrolysis gave 5-deoxy-D-lyxose. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Electric Literature of 38838-06-1

The Article related to adenine deoxypentenofuranosyl, pentenofuranosyl deoxy adenine, nucleoside dehydrodeoxy, lyxose deoxy, pentose deoxy, ribofuranose condensation benzamidopurine, purine benzamido condensation ribofuranose and other aspects.Electric Literature of 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On June 30, 1996, Blanchard, P.; El Kortbi, M. S.; Fourrey, J.-L.; Lawrence, F.; Robert-Gero, M. published an article.Related Products of 38838-06-1 The title of the article was Relationship between chemical structure and antileishmanial effect of sinefungin analogs. And the article contained the following:

The synthesis of various analogs of sinefungin, e.g. I (R = H, NH2), has been developed by means of an original approach which uses radical chem. The study of their biol. activities revealed that for the antileishmanial effect of sinefungin, the presence of the amino group at C-6′ in the (S)-configuration and the presence of the carboxyl group at C-9′ are necessary. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Related Products of 38838-06-1

The Article related to bactericide antileishmanial nucleoside synthesis, structure activity antileishmanial nucleoside synthesis, nucleoside synthesis antileishmanial effect, sinefungin analog synthesis antileishmanial effect and other aspects.Related Products of 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

On January 31, 1997, Zhu, Bao Hua; Liu, Ze Hua; Yan, Hong; Liu, Jun; Chen, Huilan published an article.Computed Properties of 38838-06-1 The title of the article was The coenzyme B12 analogs-ribosylcobalamins: synthesis, characterization, and photolysis studies. And the article contained the following:

Two analogs of Coenzyme B12, i.e., 1-methyl-5-deoxy-β-D(-)ribofuranos-5-ylcobalamin (RibCbl) and 1-methyl-5-deoxy-2,3-isopropylidene-β-D(-)-ribofuranos-5-yl-cobalamin(RibCbl*), were synthesized. They were characterized by UV-vis and 2D 1H NMR spectroscopies. Furthermore, aerobic and anaerobic photolysis of the two compounds have been studied. Kinetic data of anaerobic photoinduced homolysis for two ribosylcobalamin(AdoCbl) have been determined The half-times under the same exptl. conditions are: RibCbl*, t1/2 = 488 min; RibCbl, t1/2 = 122 min; and AdoCbl, t1/2 = 3 min, resp. Therefore, both of ribosylcobalamins are less photosensitive than Coenzyme B12. These results are discussed in terms of the in-cage chem. process as well as steric and electronic effects of the axial ligand on the Co-C bond homolysis. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Computed Properties of 38838-06-1

The Article related to steric effect bond homolysis methyldeoxyribofuranosylcobalamin preparation, methyldeoxyribofuranosylcobalamin aerobic anaerobic photolysis kinetics, coenzyme b12 analog ribosylcobalamin preparation photolysis and other aspects.Computed Properties of 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem