Month: April 2022

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6,7-Dichlorobenzo[d]thiazol-2-amine, is researched, Molecular C7H4Cl2N2S, CAS is 25150-27-0, about Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3, the main research direction is SAR preparation androstenedione hydroxysteroid dehydrogenase tetrahydrodibenzazocine derivative.Computed Properties of C7H4Cl2N2S.

A novel series of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17β-HSD3 in cell-free enzymic as well as in cell-based transcriptional reporter assays.

There is still a lot of research devoted to this compound(SMILES：NC1=NC2=CC=C(Cl)C(Cl)=C2S1)Computed Properties of C7H4Cl2N2S, and with the development of science, more effects of this compound(25150-27-0) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Nallagonda, Rajender; Karimov, Rashad R. published the article 《Copper-Catalyzed Regio- and Diastereoselective Additions of Boron-Stabilized Carbanions to Heteroarenium Salts: Synthesis of Azaheterocycles Containing Contiguous Stereocenters》. Keywords: nonaromatic nitrogen heterocycle preparation diastereoselective addition boron carbanion heteroarenium.They researched the compound: Methyl 5-fluoro-3-pyridinecarboxylate( cas:455-70-9 ).Product Details of 455-70-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:455-70-9) here.

Nucleophilic addition of diborylalkyl reagents to N-alkyl or N-acylpyridinium and related heteroarenium salts has been developed as a key step for the synthesis of nonaromatic nitrogen heterocycles that contain contiguous stereogenic centers. Derivatization of the dihydropyridine products for the synthesis of tetrahydropyridines and piperidines have also been described.

There is still a lot of research devoted to this compound(SMILES：COC(=O)C1=CC(F)=CN=C1)Product Details of 455-70-9, and with the development of science, more effects of this compound(455-70-9) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, is researched, Molecular C34H22NO2P, CAS is 1265884-98-7, about Iridium-catalyzed enantioselective allylic substitution with aqueous solutions of nucleophiles.Formula: C34H22NO2P.

The iridium-catalyzed asym. allylic substitution under biphasic conditions is reported. This approach allows the use of various unstable and/or volatile nucleophiles including hydrazines, methylamine, t-Bu hydroperoxide, N-hydroxylamine, α-chloroacetaldehyde and glutaraldehyde. This transformation provides rapid access to a broad range of products from simple starting materials in good yields and up to >99% ee and 20:1 d.r. Addnl., these products can be elaborated efficiently into a diverse set of cyclic and acyclic compounds, bearing up to four stereocenters. The iridium-catalyzed asym. allylic substitution under biphasic conditions is reported. This approach allows the use of various unstable and/or volatile nucleophiles including hydrazines, methylamine, t-Bu hydroperoxide, N-hydroxylamine, α-chloroacetaldehyde and glutaraldehyde. This transformation provides rapid access to a broad range of products from simple starting materials in good yields and up to >99% ee and 20:1 d.r.. Addnl., these products can be elaborated efficiently into a diverse set of cyclic and acyclic compounds, bearing up to four stereocenters.

There is still a lot of research devoted to this compound(SMILES：N1(P2OC3=CC=C4C=CC=CC4=C3C5=C6C=CC=CC6=CC=C5O2)C7=CC=CC=C7C=CC8=CC=CC=C81)Formula: C34H22NO2P, and with the development of science, more effects of this compound(1265884-98-7) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Zhou, Zhenhua published the article 《A chiral shift reagent for measurement of optical purities of chiral phosphine oxides》. Keywords: phosphine oxide optical purity determination; NMR phosphine oxide optical purity determination; phenylmethylphospholene optical purity determination; phospholene methylphenyl optical purity determination; nitrobenzoylphenylethylamine chiral shift reagent NMR.They researched the compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide( cas:707-61-9 ).HPLC of Formula: 707-61-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:707-61-9) here.

(R)-(-)-N-(3,5-Dinitrobenzyl)-α-phenylethylamine (I) is an excellent chiral shift reagent for measurement of optical purities of chiral phosphine oxides. The method of preparation and application of reagent I are discussed in detail. 1-Phenyl-3-methyl-2-phospholene(II) is oxidized to 1-phenyl-3-methyl-2-phospholene 1-oxide (III) which is then reacted with tert-BuOOH with complete retention of optical activity. When phosphine oxide is mixed with reagent(I), optical purity of phosphine oxide can be measured according to 1H NMR spectra; the optical purity of II can be determined

There is still a lot of research devoted to this compound(SMILES：CC1=CP(CC1)(C2=CC=CC=C2)=O)HPLC of Formula: 707-61-9, and with the development of science, more effects of this compound(707-61-9) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called Trimethyl Orthoacetate and Ethylene Glycol Mono-Vinyl Ether as Enolate Surrogates in Enantioselective Iridium-Catalyzed Allylation, Author is Sempere, Yeshua; Carreira, Erick M., which mentions a compound: 1265884-98-7, SMILESS is N1(P2OC3=CC=C4C=CC=CC4=C3C5=C6C=CC=CC6=CC=C5O2)C7=CC=CC=C7C=CC8=CC=CC=C81, Molecular C34H22NO2P, Product Details of 1265884-98-7.

Tri-Me orthoacetate and ethylene glycol mono-vinyl ether are employed in iridium-catalyzed enantioselective allylation reactions. The method documented enables their convenient use as surrogates for silyl ketene acetals and silyl enol ethers to prepare γ,δ-unsaturated esters and protected aldehydes with excellent enantioselectivity. The utility of this novel method has been demonstrated by its implementation in a formal enantioselective synthesis of the meroterpenoid (+)-conicol.

There is still a lot of research devoted to this compound(SMILES：N1(P2OC3=CC=C4C=CC=CC4=C3C5=C6C=CC=CC6=CC=C5O2)C7=CC=CC=C7C=CC8=CC=CC=C81)Product Details of 1265884-98-7, and with the development of science, more effects of this compound(1265884-98-7) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Recommanded Product: 1265884-98-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, is researched, Molecular C34H22NO2P, CAS is 1265884-98-7, about Iridium-Catalyzed Enantioselective Allyl-Allyl Cross-Coupling of Racemic Allylic Alcohols with Allylboronates. Author is Zheng, Yu; Yue, Bei-Bei; Wei, Kun; Yang, Yu-Rong.

Carreira’s iridium-(P, olefin) phosphoramidite-based catalytic system that allows asym. allyl-allylboronate cross-coupling with high enantioselectivity is reported. This transformation tolerates a large variety of racemic branched allylic alcs. and allylboronate substrates. The utility of the coupling is demonstrated in a concise catalytic asym. synthesis of (-)-preclamol (I).

There is still a lot of research devoted to this compound(SMILES：N1(P2OC3=CC=C4C=CC=CC4=C3C5=C6C=CC=CC6=CC=C5O2)C7=CC=CC=C7C=CC8=CC=CC=C81)Recommanded Product: 1265884-98-7, and with the development of science, more effects of this compound(1265884-98-7) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Improved syntheses and characterization of the isomers of 3-methyl-1-phenylphospholene 1-oxide, the main research direction is phospholene oxide isomer; NMR phospholene oxide; IR phospholene oxide; Raman laser phospholene oxide; mass spectra phospholene oxide.Recommanded Product: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide.

Isomerically pure 3-methyl-1-phenyl-2-phospholene 1-oxide and 3-methyl-1-phenyl-3-phospholene 1-oxide were prepared and characterized by 1H (60 and 270 MHz), 31P and 13C NMR, IR, Laser Raman, and mass spectrometry. 1,4-Cycloaddition of isoprene and PhPCl2 after hydrolysis of the addition product, yielded a mixture of the above 2-isomer and small amounts of 3-isomer from which pure 2-isomer was separated by fractional crystallization The analog reaction with PhPBr2 gave isomerically pure 3-isomer. An improved and shortened work-up procedure for the phospholene oxides was used resulting in higher yields.

There is still a lot of research devoted to this compound(SMILES：CC1=CP(CC1)(C2=CC=CC=C2)=O)Recommanded Product: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, and with the development of science, more effects of this compound(707-61-9) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ) is researched.Recommanded Product: 2-Bromomethyl-1,3-dioxolane.Nedolya, N. A.; Tarasova, O. A.; Albanov, A. I.; Trofimov, B. A. published the article 《Synthesis and Unexpected Transformation of 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amine into 5-{[2-(2-Hydroxyethoxy)ethenyl]sulfanyl}-1H-pyrrol-2-amine in the Presence of a Superbase》 about this compound( cas:4360-63-8 ) in Russian Journal of Organic Chemistry. Keywords: ethenyloxyethyl diethyl hydroxyethoxy ethenylsulfanyl pyrrolamine preparation diastereoselective; dioxolanylmethylsulfanyl ethenyloxyethyl diethylpyrrolamine preparation one pot transformation potassium butoxide; diethylpropynamine ethenyloxyethyl isothiocyanate bromomethyl dioxolane cyclization potassium butoxide. Let’s learn more about this compound (cas:4360-63-8).

Successive one-pot reactions of monolithiated N,N-diethylprop-2-yn-1-amine with 2-(ethenyloxy)ethyl isothiocyanate and 2-(bromomethyl)-1,3-dioxolane afforded I in 91% yield. In the system t-BuOK-DMSO at room temperature (1 h), the product was converted to E/Z-II (yield 68%) instead of expected 1-vinyl derivative

There is still a lot of research devoted to this compound(SMILES：BrCC1OCCO1)Recommanded Product: 2-Bromomethyl-1,3-dioxolane, and with the development of science, more effects of this compound(4360-63-8) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Enantioselective Synthesis of 7(S)-Hydroxydocosahexaenoic Acid, a Possible Endogenous Ligand for PPARα.Category: dioxole.

We report the first total synthesis of the polyunsaturated fatty acid 7-hydroxydocosahexaenoic acid (7-HDHA) in racemic form and the enantioselective synthesis of 7-(S)-HDHA. Both syntheses follow a convergent approach that unites the C1-C9 and C10-C22 fragments using Sonogashira coupling and Boland reduction as key steps. These syntheses enabled the unambiguous characterization of this natural product for the first time and helped establish 7(S)-HDHA as a possible endogenous ligand for peroxisome proliferator-activated receptor alpha.

There is still a lot of research devoted to this compound(SMILES：BrCC1OCCO1)Category: dioxole, and with the development of science, more effects of this compound(4360-63-8) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application of 1265884-98-7. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, is researched, Molecular C34H22NO2P, CAS is 1265884-98-7, about Iridium-Catalyzed Enantioselective Allylation of Aryl Enamides and Enecarbamates. Author is Yue, Bei-Bei; Deng, Yi; Zheng, Yu; Wei, Kun; Yang, Yu-Rong.

Aromatic enamide and enecarbamate as a novel type of nucleophile in the asym. allylation of branched, racemic allylic alcs. to give homoallylic ketones has been described. Enabled by Carreira’s chiral Ir (P, olefin) complex, the reactions proceed in good yields with excellent enantioselectivities.

There is still a lot of research devoted to this compound(SMILES：N1(P2OC3=CC=C4C=CC=CC4=C3C5=C6C=CC=CC6=CC=C5O2)C7=CC=CC=C7C=CC8=CC=CC=C81)Application of 1265884-98-7, and with the development of science, more effects of this compound(1265884-98-7) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem