Month: April 2022

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Investigations on the isomerization of ring-substituted derivatives of 3-nitraminopyridines. I. Chloro-3-nitraminopyridines》. Authors are Czuba, Wladyslaw.The article about the compound:5-Chloropyridin-3-aminecas:22353-34-0,SMILESS:NC1=CC(=CN=C1)Cl).HPLC of Formula: 22353-34-0. Through the article, more information about this compound (cas:22353-34-0) is conveyed.

6-(m. 139°), 2- (m. 100-3°), 5- (m. 146°), and 4-Chloro-3-nitraminopyridine (m. 179°) (all with decomposition) heated to 40° in concentrated H2SO4 underwent isomerization to 6,6′-dichloro- (I) (m. 215-17°, yield 10%) and 6,6′-dichloro-2-nitro- (II) (m. 165°, 9%), 2,2′-dichloro- (III) (m. 237-9°, 26%), 5,5′-dichloro- 3, 3′-azopyridine (IV) (m. 183°, 16%) and 5-chloro-3-hydroxypyridine (m. 158°, 32%), and 4,4′-dichloro-3,3′-azopyridine (V) (m. 164°, 40%), resp. I, III, IV, and V with SnCl2, Sn, or NaSH gave the hydrazopyridines, m. 183-5°, 209°, 128-31°, and 172°, resp., yields 70-91%. Reduction of III yielded 6-chloro-2,3-diamino- and -3-aminopyridine. A new method of preparation of 3-amino-5-chloropyridine (VI) was described. Br (32 g.) dissolved in 25 g. NaOH, 50 ml. H2O, and 250 g. ice, 25.5 g. 5-chloronicotinic acid amide added, the mixture heated 0.5 hr. at 75°, the solution saturated with NaCl, extracted with Et2O, dried (K2CO3), and evaporated gave 83% VI, m. 82° (C6H6 + ligroine).

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues, published in 2021-05-01, which mentions a compound: 7524-52-9, mainly applied to ianthelliformisamine derivative preparation antibacterial; subereamine analog preparation; Bromotyrosine; Ianthelliformisamines; Marine sponges; Suberea; Subereamines, HPLC of Formula: 7524-52-9.

Marine sponges of the genus Suberea produce a variety of brominated tyrosine alkaloids which display a diverse range of biol. activities including antiproliferative, antimicrobial and antimalarial activities. In continuation of our search for biol. active marine natural products as antibacterial compounds, we report here the synthesis and evaluation of the biol. activity of a panel of ianthelliformisamines and subereamine analogs using the literature-known acid-amine coupling reaction. Several derivatives of ianthelliformisamine were obtained by coupling Boc-protected polyamines with brominated aromatic acrylic acid derivatives followed by Boc-deprotection using TFA. The aromatic acrylic acid derivatives varied in bromine substitution and geometry of the double bond. Similarly, subereamine analogs were synthesized by employing the coupling reaction between various brominated phenylacrylic acids with com. available chiral amino ester derivatives followed by ester hydrolysis. These synthetic analogs were screened for antibacterial activity against both Gram-neg. (Escherichia coli) and Gram-pos. (Staphylococcus aureus) strains. Ianthelliformisamine derivative I showed bactericidal activity against Staphylococcus aureus with an IC50 value of 3.8μM (MIC = 25μM).

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Iridium-Catalyzed Enantioconvergent Allylation of a Boron-Stabilized Organozinc Reagent, published in 2021-07-16, which mentions a compound: 1265884-98-7, Name is 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, Molecular C34H22NO2P, Safety of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine.

An Ir-catalyzed enantioconvergent coupling of the versatile B-stabilized organozinc reagent BpinCH2ZnI with a racemic branched allylic carbonate was developed here, which differs from the authors’ previous work by using 1,1-bisborylmethane through the kinetic resolution process. The reaction has a broad substrate scope, and various chiral homoallylic organoboronic esters could be obtained in good yields with excellent enantioselectivities. The synthetic practicability of the products was demonstrated by their conversion to other useful families of compounds

As far as I know, this compound(1265884-98-7)Safety of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Rhodium-catalyzed asymmetric arylative cyclization of meso-1,6-dienynes leading to enantioenriched cis-hydrobenzofurans, published in 2013, which mentions a compound: 1265884-98-7, mainly applied to hydrobenzofuran enantioselective preparation; dienyne arylboronic acid tandem arylation cyclization rhodium catalyst, Category: dioxole.

A tandem rhodium-catalyzed asym. arylative cyclization of cyclohexadienone-containing meso-1,6-dienynes is developed. A series of optically pure cis-hydrobenzofurans were obtained with high to excellent yields (80-99%) and excellent enantioselectivities (95-99% ee). The utility of this method was demonstrated by transforming the cyclization products to chiral frameworks of some natural products.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Methyl 5-fluoro-3-pyridinecarboxylate, is researched, Molecular C7H6FNO2, CAS is 455-70-9, about A general synthesis of substituted fluorenones and azafluorenones.Safety of Methyl 5-fluoro-3-pyridinecarboxylate.

Twenty-one variously substituted fluorenones and azafluorenones I (X, X1, X2 = CH, N; R, R1 = H, alkyl, halo, etc.) were prepared The key ring-forming step was photochem. Pschorr cyclization of 2-diazoniodiaryl ketones II (same R, R1, X-X2) under direct, (bpy)3Ru(II)- (bpy = 2,2′-bipyridine), or (bpy)3Ru(II)-Cu(II)-photosensitized conditions. Where selectivities were possible in the ring closure, the isomer ratios obtained were in accord with an intermediate aryl radical.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Design, synthesis and evaluation of PD176252 analogues for ameliorating cisplatin-induced nephrotoxicity.Related Products of 7524-52-9.

Cisplatin is a clin. chemotherapy drug for cancers; however, its remarkably high kidney toxicity and other toxicities pose a danger to patients. As the small mol. inhibitor of GRPR, PD176252 can inhibit the growth and proliferation of various cancer cells, but the characteristics of high toxicity and poor water solubility has limited its use as a drug. When we studied PD176252 for the reduction of toxicity of cisplatin, we modified its structure to synthesize 16 analogs. Surprisingly, the analogs showed reduced cisplatin-induced renal toxicity, and unlike PD176252, the analogs 5d and 5m were almost non-toxic to the normal HK2 cells. Furthermore, the analog 5d and PD176252 were subjected to cisplatin-induced inflammatory response in vitro. The results showed that 5d was able to better prevent this condition by effectively inhibiting its inflammatory response. Thus, this study will help in clin. reducing the side effects of cisplatin.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Reference of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, is researched, Molecular C34H22NO2P, CAS is 1265884-98-7, about Rhodium-catalyzed asymmetric arylative cyclization of meso-1,6-dienynes leading to enantioenriched cis-hydrobenzofurans. Author is He, Zhi-Tao; Tian, Bing; Fukui, Yuki; Tong, Xiaofeng; Tian, Ping; Lin, Guo-Qiang.

A tandem rhodium-catalyzed asym. arylative cyclization of cyclohexadienone-containing meso-1,6-dienynes is developed. A series of optically pure cis-hydrobenzofurans were obtained with high to excellent yields (80-99%) and excellent enantioselectivities (95-99% ee). The utility of this method was demonstrated by transforming the cyclization products to chiral frameworks of some natural products.

This literature about this compound(1265884-98-7)Reference of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepinehas given us a lot of inspiration, and I hope that the research on this compound(5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of C5-Allylindoles through an Iridium-Catalyzed Asymmetric Allylic Substitution/Oxidation Reaction Sequence of N-Alkyl Indolines, published in 2021-05-07, which mentions a compound: 1265884-98-7, mainly applied to allylindoline preparation enantioselective DFT study; allylindole preparation enantioselective DFT study; alkyl indoline allylic alc tandem reaction iridium catalyst, Reference of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine.

Iridium/Bronsted acid cooperative catalyzed asym. allylic substitution reactions at the C5 position of indolines I (R = Bn, PMB; R1 = 2-Me, 2-Ph, 2,3-(Me)2, etc.) have been reported for the first time. The highly efficient protocol allows rapid access to various C5-allylated products (R/S)-II (Ar = C6H5, 2-BrC6H4, 2-naphthyl, etc.) and III in good to high yields (48-97%) and enantioselectivities (82% to >99% ee) with wide functional group tolerance. The transformations allow not only the formation of C5-allylindoline derivatives II but also the synthesis of C5-allylindoles III in good yields and excellent stereoselectivities via an allylation/oxidation reaction sequence.

This literature about this compound(1265884-98-7)Reference of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepinehas given us a lot of inspiration, and I hope that the research on this compound(5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine( cas:1265884-98-7 ) is researched.HPLC of Formula: 1265884-98-7.Sempere, Yeshua; Alfke, Jan L.; Roessler, Simon L.; Carreira, Erick M. published the article 《Morpholine Ketene Aminal as Amide Enolate Surrogate in Iridium-Catalyzed Asymmetric Allylic Alkylation》 about this compound( cas:1265884-98-7 ) in Angewandte Chemie, International Edition. Keywords: morpholine ketene aminal amide enolate surrogate asym allylic alkylation; iridium catalyzed asym allylic alkylation morpholine ketene aminal; alkylation; allylation; amides; enantioselectivity; iridium. Let’s learn more about this compound (cas:1265884-98-7).

Morpholine ketene aminal is employed in iridium-catalyzed asym. allylic alkylation reactions as a surrogate for amide enolates to prepare γ,δ-unsaturated β-substituted morpholine amides. Kinetic resolution or, alternatively, stereospecific substitution affords the corresponding products in high enantiomeric excess [e.g., (±)-I + II → (R)-III + (S)-I]. The utility of the products generated by this method has been showcased by their further elaboration into amines, ketones, or acyl silanes. A putative catalytic intermediate (η3-allyl)iridium(III) with achiral P,olefin-ligand was synthesized and characterized for the first time.

This literature about this compound(1265884-98-7)HPLC of Formula: 1265884-98-7has given us a lot of inspiration, and I hope that the research on this compound(5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Name: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, is researched, Molecular C34H22NO2P, CAS is 1265884-98-7, about Construction of Vicinal Quaternary Centers via Iridium-Catalyzed Asymmetric Allenylic Alkylation of Racemic Tertiary Alcohols. Author is Isomura, Mayuko; Petrone, David A.; Carreira, Erick M..

Enantioselective bond formation between sterically hindered fragments to furnish acyclic products with vicinal quaternary centers is a formidable challenge. We report a solution that involves cocatalysis between a chiral Ir-(phosphoramidite, olefin) complex and La(OTf)3. This robust catalytic system effects highly enantioconvergent and regioselective alkylation of racemic tertiary α-allenyl alcs. with tetrasubstituted silyl ketene acetals. The transformation displays broad functional group tolerance for both reaction components and allows efficient generation of β-allenyl ester products in good yield and with excellent enantioselectivity. Furthermore, both the allene and ester functionalities were leveraged to upgrade the structural complexity of the products via a series of stereoselective metal-catalyzed functionalization reactions.

This literature about this compound(1265884-98-7)Name: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepinehas given us a lot of inspiration, and I hope that the research on this compound(5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem