Month: April 2022

Reference of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, is researched, Molecular C34H22NO2P, CAS is 1265884-98-7, about Diastereo- and Enantioselective Synthesis of Borylated 3-Hydroxyoxindoles by Addition of gem-Diborylalkanes to Isatins. Author is Zhou, Yuan; Xiong, Tong; Zhou, Li-Yan; Li, Hong-Yan; Xiao, You-Cai; Chen, Fen-Er.

The catalytic asym. synthesis of borylated 3-hydroxyoxindoles by addition of gem-diborylalkanes to isatins is disclosed. Chiral 3-hydroxyoxindoles bearing two contiguous stereogenic centers were produced in up to >20:1 dr and 99% ee. The synthetic utility of the corresponding products is presented through several transformations of the boryl moiety. This report provides an efficient strategy to incorporate a boryl functional group toward the synthesis of 3-hydroxyoxindoles.

After consulting a lot of data, we found that this compound(1265884-98-7)Reference of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, ACS Omega called Bioinspired Bronsted Acid-Promoted Regioselective Tryptophan Isoprenylations, Author is Khopade, Tushar M.; Ajayan, Kalyani; Joshi, Swapnil S.; Lane, Amy L.; Viswanathan, Rajesh, which mentions a compound: 7524-52-9, SMILESS is N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl, Molecular C12H15ClN2O2, Electric Literature of C12H15ClN2O2.

Tryptophan-containing isoprenoid indole alkaloid natural products are well known for their intricate structural architectures and significant biol. activities. Nature employs dimethylallyl tryptophan synthases (DMATSs) or aromatic indole prenyltransferases (iPTs) to catalyze regio- and stereoselective prenylation of L-Trp. Regioselective synthetic routes that isoprenylate cyclo-Trp-Trp in a 2,5-diketopiperazine (DKP) core, in a desymmetrizing manner, are nonexistent and are highly desirable. Herein, we present an elaborate report on Bronsted acid-promoted regioselective tryptophan isoprenylation strategy, applicable to both the monomeric amino acid and its dimeric L-Trp DKP. This report outlines a method that regio- and stereoselectively increases sp3 centers of a privileged bioactive core. We report on conditions involving screening of Bronsted acids, their conjugate base as salt, solvent, temperature, and various substrates with diverse side chains. Furthermore, we extensively delineate effects on regio- and stereoselection of isoprenylation and their stereochem. confirmation via NMR experiments Regioselectively, the C3-position undergoes normal-isoprenylation or benzylation and forms exo-ring-fused pyrroloindolines selectively. Through appropriate prenyl group migrations, we report access to the bioactive tryprostatin alkaloids, and by C3-normal-farnesylation, we access anticancer drimentines as direct targets of this method. The optimized strategy affords iso-tryprostatin B-type products and predrimentine C with 58 and 55% yields, resp. The current work has several similarities to biosynthesis, such as (1) reactions can be performed on unprotected substrates, (2) conditions that enable Bronsted acid promotion, and (3) they are easy to perform under ambient conditions, without the need for stoichiometric levels of any transition metal or expensive ligands.

After consulting a lot of data, we found that this compound(7524-52-9)Electric Literature of C12H15ClN2O2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of Nitrogen-Containing Heterocycles and Cyclopentenone Derivatives via Phosphine-Catalyzed Michael Addition/Intramolecular Wittig Reaction, published in 2017, which mentions a compound: 707-61-9, mainly applied to diketone cyclocondensation acetylenedicarboxylate phosphine catalyst; pyrrolizidine pyrroline pyridine cyclopentenone preparation; acetylenedicarboxylate amino carbaldehyde ester Michael addition intramol Wittig, SDS of cas: 707-61-9.

The phosphine-catalyzed Michael addition/intramol. Wittig reaction between dialkyl acetylenedicarboxylate and amino carboxaldehyde or amino ester has been developed. This reaction can be rendered catalytic in phosphine by the in situ chemoselective reduction of the phosphine oxide with a silane. This methodol. enables rapid access to a variety of nitrogen-containing heterocycles, which are present in numerous natural products and/or bioactive compounds Either classical heating or microwave conditions give access to the desired products in good yields (15 examples, 60-99% yields). This catalytic methodol. is further applicable to the synthesis of enantioenriched 1H-pyrrole derivatives, with the use of chiral phosphines. Finally, the reaction is extended to the synthesis of a polysubstituted cyclopentenone, starting from butane-2,3-dione as substrate.

After consulting a lot of data, we found that this compound(707-61-9)SDS of cas: 707-61-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1265884-98-7, is researched, SMILESS is N1(P2OC3=CC=C4C=CC=CC4=C3C5=C6C=CC=CC6=CC=C5O2)C7=CC=CC=C7C=CC8=CC=CC=C81, Molecular C34H22NO2PJournal, Article, Angewandte Chemie, International Edition called Iridium-Catalyzed Enantioselective Allylic Alkylation with Functionalized Organozinc Bromides, Author is Hamilton, James Y.; Sarlah, David; Carreira, Erick M., the main research direction is carbonate racemic enantioselective regioselective allylic alkylation organozinc iridium catalyst; alkene branched asym synthesis; alkylation; allylic compounds; enantioselectivity; iridium; zinc.Electric Literature of C34H22NO2P.

Iridium-catalyzed enantioselective allylic alkylation of branched racemic carbonates R1CH(OBoc)CH:CH2 (R1 = MeCH:CH, Ph, 3-MeOC6H4, 3-thienyl, 2-naphthyl, PhCH2CH2CC, etc.) with functionalized alkylzinc bromide reagents R2ZnBr [R2 = EtO2C(CH2)3, NC(CH2)4, 1,3-dioxolan-2-ylmethyl, etc.] is described. Enabled by a chiral Ir/(P,olefin) complex, this method allows allylic substitution with various primary and secondary alkyl nucleophiles with excellent regio- and enantioselectivities. The developed reaction was showcased in a concise, asym. synthesis of (-)-preclamol.

After consulting a lot of data, we found that this compound(1265884-98-7)Electric Literature of C34H22NO2P can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Kinetic Resolution of Spiroindolines through Ir-Catalyzed Asymmetric Allylative Ring-Opening Reaction, published in 2021-09-03, which mentions a compound: 1265884-98-7, Name is 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, Molecular C34H22NO2P, Synthetic Route of C34H22NO2P.

Kinetic resolution of racemic spiroindolines I [R = H, Me, MeO, F, Cl; X = H, Me, Cl; Y = H, Me, MeO, F, Cl; Z = H, Me, MeO, F; no stereo] with s factors of ≤15200 was developed to access enantiomerically enriched indole-annulated medium-sized lactams II [R1 = Ph, 2-thienyl, 2-naphthyl, etc.] and spiroindolines I [stereo = R] through Ir-catalyzed asym. allylative ring-opening reaction. D. functional theory calculations supported the idea that the accurate discrimination of two spiroindoline enantiomers by (η3-allyl)-iridium(III) species and the perfect central-to-axial chirality conversion during C-C bond fragmentation ensure the stereoselective formation of two contiguous stereogenic centers and one axis in the medium-sized lactams.

After consulting a lot of data, we found that this compound(1265884-98-7)Synthetic Route of C34H22NO2P can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Safety of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, is researched, Molecular C34H22NO2P, CAS is 1265884-98-7, about Origin of Stereodivergence in Cooperative Asymmetric Catalysis with Simultaneous Involvement of Two Chiral Catalysts.

Accomplishing high diastereo- and enantioselectivities simultaneously is a persistent challenge in asym. catalysis. The use of two chiral catalysts in one-pot conditions might offer new avenues to this end. Chirality transfer from a catalyst to product gets increasingly complex due to potential chiral match-mismatch issues. The origin of high enantio- and diastereoselectivities in the reaction between a racemic aldehyde and an allyl alc., catalyzed by using axially chiral iridium phosphoramidites PR/S-Ir and cinchona amine is established through transition-state modeling. The multipoint contact anal. of the stereocontrolling transition state revealed how the stereodivergence could be achieved by inverting the configuration of the chiral catalysts that are involved in the activation of the reacting partners. While the enantiocontrol is identified as being decided in the generation of PR/S-Ir-π-allyl intermediate from the allyl alc., the diastereocontrol arises due to the differential stabilizations in the C-C bond formation transition states. The anal. of the weak interactions in the transition states responsible for chiral induction revealed that the geometric disposition of the quinoline ring at the C8 chiral carbon of cinchona-enamine plays an anchoring role. The quinolone ring is noted as participating in a π-stacking interaction with the Ph ring of the Ir-π-allyl moiety in the case of PR with the (8R,9R)-cinchona catalyst combination, whereas a series of C-H···π interactions is identified as vital to the relative stabilization of the stereocontrolling transition states when PR is used with (8S,9S)-cinchona.

After consulting a lot of data, we found that this compound(1265884-98-7)Safety of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromomethyl-1,3-dioxolane(SMILESS: BrCC1OCCO1,cas:4360-63-8) is researched.Safety of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine. The article 《Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives》 in relation to this compound, is published in Chemical Science. Let’s take a look at the latest research on this compound (cas:4360-63-8).

An efficient protocol for the modular synthesis of sulfones and sulfonyl derivatives RS(O)2R1 (R = 3-phenylpropyl, Ph, naphthalen-2-yl, etc.; R1 = [(tert-butyldimethylsilyl)oxy]methyl, 4-(morpholin-4-yl)phenyl, hex-5-yn-1-yl, etc.) has been developed utilizing sodium tert-butyldimethylsilyloxymethanesulfinate (TBSOMS-Na) as a sulfoxylate (SO22-) equivalent TBSOMS-Na, easily prepared from the com. reagents Rongalite and TBSCl, serves as a potent nucleophile in S-alkylation and Cu-catalyzed S-arylation reactions with alkyl and aryl electrophiles R1X (X = I, Br). The sulfone products thus obtained can undergo the second bond formation at the sulfur center with various electrophiles without a sep. unmasking step to afford sulfones and sulfonyl derivatives such as sulfonamides and sulfonyl fluorides.

After consulting a lot of data, we found that this compound(4360-63-8)Computed Properties of C4H7BrO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Iridium-Catalyzed Enantioconvergent Allylation of a Boron-Stabilized Organozinc Reagent, published in 2021-07-16, which mentions a compound: 1265884-98-7, Name is 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, Molecular C34H22NO2P, Safety of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine.

An Ir-catalyzed enantioconvergent coupling of the versatile B-stabilized organozinc reagent BpinCH2ZnI with a racemic branched allylic carbonate was developed here, which differs from the authors’ previous work by using 1,1-bisborylmethane through the kinetic resolution process. The reaction has a broad substrate scope, and various chiral homoallylic organoboronic esters could be obtained in good yields with excellent enantioselectivities. The synthetic practicability of the products was demonstrated by their conversion to other useful families of compounds

After consulting a lot of data, we found that this compound(1265884-98-7)Safety of 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: H-Trp-OMe.HCl(SMILESS: N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl,cas:7524-52-9) is researched.Quality Control of 2-Bromo-6-(bromomethyl)naphthalene. The article 《Visible-light mediated tryptophan modification in oligopeptides employing acylsilanes》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:7524-52-9).

A method for the selective tryptophan modification and labeling of tryptophan-containing peptides is described. Photoirradiation of acylsilanes generates reactive siloxycarbenes which undergo H-N-insertion into the indole moiety of tryptophan to give stable silyl protected hemiaminals. This method is successfully applied to chem. modify various tryptophan containing oligopeptides. The method enables the selective introduction of alkynes to peptides that are eligible for further alkyne-azide click chem. In addition, the dansyl fluorophore can be conjugated to a peptide using this approach.

After consulting a lot of data, we found that this compound(7524-52-9)Synthetic Route of C12H15ClN2O2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromo-6-(bromomethyl)naphthalene(SMILESS: BrCC1=CC2=CC=C(Br)C=C2C=C1,cas:305798-02-1) is researched.Related Products of 1265884-98-7. The article 《Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:305798-02-1).

The N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel activated by L-glutamate and glycine, plays a major role in the synaptic plasticity underlying learning and memory. NMDARs are involved in neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease and NMDAR hypofunction is implicated in schizophrenia. Herein we describe structure-activity relationship (SAR) studies on 2-naphthoic acid derivatives to investigate structural requirements for pos. and neg. allosteric modulation of NMDARs. These studies identified compounds such as UBP684 (14b), which act as pan potentiators by enhancing NMDAR currents in diheteromeric NMDAR tetramers containing GluN1 and GluN2A-D subunits. 14B and derivatives thereof are useful tools to study synaptic function and have potential as leads for the development of drugs to treat schizophrenia and disorders that lead to a loss of cognitive function. In addition, SAR studies have identified a series of styryl substituted compounds with partial NAM activity and a preference for inhibition of GluN2D vs. the other GluN2 subunits. In particular, the 3-and 2-nitrostyryl derivatives UBP783 (79i) and UBP792 (79h) had IC50s of 1.4 μM and 2.9 μM, resp., for inhibition of GluN2D but showed only 70-80% maximal inhibition. GluN2D has been shown to play a role in excessive pain transmission due to nerve injury and potentially in neurodegenerative disorders. Partial GluN2D inhibitors may be leads for the development of drugs to treat these disorders without the adverse effects observed with full NMDAR antagonists.

After consulting a lot of data, we found that this compound(305798-02-1)Quality Control of 2-Bromo-6-(bromomethyl)naphthalene can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem