Day: April 20, 2022

Lu, Meng-Chen; Zhang, Xian; Wu, Feng; Tan, Shi-Jie; Zhao, Jing; You, Qi-Dong; Jiang, Zheng-Yu published an article about the compound: H-Trp-OMe.HCl( cas:7524-52-9,SMILESS:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl ).Safety of H-Trp-OMe.HCl. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:7524-52-9) through the article.

The transcription factor Nrf2 is a key regulator of cytoprotective system, and enhancing Nrf2 activity can protect cells from various insults and threats. Directly disrupting Keap1-Nrf2 protein-protein interactions has been regarded as a promising way to activate Nrf2. We reported here the first identification of amino acids as preferred substituents to design potent Keap1-Nrf2 inhibitors. Comprehensive structure-activity anal. identified Pro as a preferred substituent, obtaining a potent inhibitor 35 with an IC50 of 43 nM in the competitive fluoresce polarization (FP) assay and a Kd value of 53.7 nM for Keap1 protein in the isothermal titration calorimetry (ITC) assay. The Pro analog 35 exhibited tight and prolonged Keap1 binding in vitro and in cells, and treatment with 35 activated Nrf2-regulated cytoprotective response and antagonized acetaminophen-induced liver injury both in cellular and in vivo models. This work not only provides a useful tool to further explore the therapeutic potential of Keap1-Nrf2 inhibition but also enriches the diversity of chem. structures suitable for the Keap1-Nrf2 interface.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tong, Rong; Pang, Xiaoyan; Sun, Jing; Ding, Zhiwen; Jia, Jizhang researched the compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide( cas:707-61-9 ).SDS of cas: 707-61-9.They published the article 《Synthesis and application of aqueous polycarbodiimide crosslinking agent(I): aqueous cationic polycarbodiimide crosslinking agent》 about this compound( cas:707-61-9 ) in Zhongguo Pige. Keywords: aqueous cationic polycarbodiimide crosslinking agent synthesis. We’ll tell you more about this compound (cas:707-61-9).

Aqueous cationic polycarbodiimide crosslinking agent was synthesized with isophorone diisocyanate (IPDI), polypropylene glycol (PPG400), N,N-dimethylethanolamine (DMEA) and 3-methyl-1-phenyl-2-phosopholene-1-oxide (MPPO) as raw materials. The influences of synthesis conditions such as the dosage of catalyst, reaction time, reaction temperature, nitrogen jet velocity, hydrophilic end-blocking agent, end-blocking temperature and the dosage of end-blocking agent on the blocking reaction were investigated. The developed crosslinking agents were applied to protein finishing agent. And it is found that the properties of obtained finishing film agent are better in the water resistance, alkali resistance, solvent resistance and flexibility. Also, the tensile strength of film increases with a little decrease in brightness and transparency.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Category: dioxole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Transition-Metal-Free Deconstructive Lactamization of Piperidines. Author is Romero-Ibanez, Julio; Cruz-Gregorio, Silvano; Sandoval-Lira, Jacinto; Hernandez-Perez, Julio M.; Quintero, Leticia; Sartillo-Piscil, Fernando.

One of the major challenges in organic synthesis is the activation or deconstructive functionalization of unreactive C(sp3)-C(sp3) bonds, which requires using transition or precious metal catalysts. We present here an alternative: the deconstructive lactamization of piperidines without using transition metal catalysts. To this end, we use 3-alkoxyamino-2-piperidones, which were prepared from piperidines through a dual C(sp3)-H oxidation, as transitory intermediates. Exptl. and theor. studies confirm that this unprecedented lactamization occurs in a tandem manner involving an oxidative deamination of 3-alkoxyamino-2-piperidones to 3-keto-2-piperidones, followed by a regioselective Baeyer-Villiger oxidation to give N-carboxyanhydride intermediates, which finally undergo a spontaneous and concerted decarboxylative intramol. translactamization.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mas-Rosello, Josep; Smejkal, Tomas; Cramer, Nicolai researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).HPLC of Formula: 4360-63-8.They published the article 《Iridium-catalyzed acid-assisted asymmetric hydrogenation of oximes to hydroxylamines》 about this compound( cas:4360-63-8 ) in Science (Washington, DC, United States). Keywords: iridium catalyzed acid assisted asym hydrogenation oxime hydroxylamine. We’ll tell you more about this compound (cas:4360-63-8).

Asym. hydrogenations are among the most practical methods for the synthesis of chiral building blocks at industrial scale. The selective reduction of an oxime to the corresponding chiral hydroxylamine derivative remains a challenging variant because of undesired cleavage of the weak nitrogen-oxygen bond. We report a robust cyclometalated iridium(III) complex bearing a chiral cyclopentadienyl ligand as an efficient catalyst for this reaction operating under highly acidic conditions. Valuable N-alkoxy amines can be accessed at room temperature with nondetected overredn. of the N-O bond [e.g., (E)-I → (S)-II (97%, 97.5:2.5 er)]. Catalyst turnover numbers up to 4000 and enantiomeric ratios up to 98:2 are observed The findings serve as a blueprint for the development of metal-catalyzed enantioselective hydrogenations of challenging substrates.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Sempere, Yeshua; Alfke, Jan L.; Roessler, Simon L.; Carreira, Erick M. published the article 《Morpholine Ketene Aminal as Amide Enolate Surrogate in Iridium-Catalyzed Asymmetric Allylic Alkylation》. Keywords: morpholine ketene aminal amide enolate surrogate asym allylic alkylation; iridium catalyzed asym allylic alkylation morpholine ketene aminal; alkylation; allylation; amides; enantioselectivity; iridium.They researched the compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine( cas:1265884-98-7 ).Electric Literature of C34H22NO2P. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1265884-98-7) here.

Morpholine ketene aminal is employed in iridium-catalyzed asym. allylic alkylation reactions as a surrogate for amide enolates to prepare γ,δ-unsaturated β-substituted morpholine amides. Kinetic resolution or, alternatively, stereospecific substitution affords the corresponding products in high enantiomeric excess [e.g., (±)-I + II → (R)-III + (S)-I]. The utility of the products generated by this method has been showcased by their further elaboration into amines, ketones, or acyl silanes. A putative catalytic intermediate (η3-allyl)iridium(III) with achiral P,olefin-ligand was synthesized and characterized for the first time.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Quality Control of H-Trp-OMe.HCl. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about A new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities. Author is Wang, Juan; Liang, Boqiang; Chen, Yiling; Fuk-Woo Chan, Jasper; Yuan, Shuofeng; Ye, Hui; Nie, Linlin; Zhou, Jiao; Wu, Yi; Wu, Meixian; Huang, Lina S.; An, Jing; Warshel, Arieh; Yuen, Kwok-Yung; Ciechanover, Aaron; Huang, Ziwei; Xu, Yan.

Inhibitors of the proteasome have been extensively studied for their applications in the treatment of human diseases such as hematol. malignancies, autoimmune disorders, and viral infections. Many of the proteasome inhibitors reported in the literature target the non-primed site of proteasome′s substrate binding pocket. In this study, we designed, synthesized and characterized a series of novel α-keto phenylamide derivatives aimed at both the primed and non-primed sites of the proteasome. In these derivatives, different substituted Ph groups at the head group targeting the primed site were incorporated in order to investigate their structure-activity relationship and optimize the potency of α-keto phenylamides. In addition, the biol. effects of modifications at the cap moiety, P1, P2 and P3 side chain positions were explored. Many derivatives displayed highly potent biol. activities in proteasome inhibition and anticancer activity against a panel of six cancer cell lines, which were further rationalized by mol. modeling analyses. Furthermore, a representative α-ketoamide derivative was tested and found to be active in inhibiting the cellular infection of SARS-CoV-2 which causes the COVID-19 pandemic. These results demonstrate that this new class of α-ketoamide derivatives are potent anticancer agents and provide exptl. evidence of the anti-SARS-CoV-2 effect by one of them, thus suggesting a possible new lead to develop antiviral therapeutics for COVID-19.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Antiparasitic thiocyanatobenzothiazoles, Author is Alaimo, Robert J.; Pelosi, Stanford S.; Hatton, Christopher J.; Gray, Joseph E., which mentions a compound: 25150-27-0, SMILESS is NC1=NC2=CC=C(Cl)C(Cl)=C2S1, Molecular C7H4Cl2N2S, Electric Literature of C7H4Cl2N2S.

A series of 7 title compound was prepared by the reaction of the appropriate aniline derivative with thiocyanogen [505-14-6] generated in situ followed by thermal cyclization. The activity of 2-amino-6-ethyl-4-thiocyanatobenzothiazole (I) [37069-20-8] against Ascaris suum and Hymenolepis nana in mice was comparable to that of dl-tetramisole [5036-02-2] and bunamidine [3748-77-4], resp. 2-Amino-7-chloro-6-fluoro-4-thiocyanatobenzothiazole (II) [37525-33-0] and 2-amino-6,7-dichloro-4-thiocyanatobenzothiazole (III) [37069-18-4] were active in vitro against several yeast species, including Candida albicans and Microsporum canis.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Chan, Hwai-Chien; Bueno, Bianca; Le Roch, Adrien; Gagnon, Alexandre published the article 《Copper-promoted N-arylation of the imidazole side chain of protected histidine by using triarylbismuth reagents》. Keywords: dipeptide arylated histidine synthesis functional group; histidine imidazole arylation copper catalyst triarylbismuth reagent; arylation reaction mechanism; N-arylation; copper catalysis; histidine; imidazole; organobismuthines.They researched the compound: H-Trp-OMe.HCl( cas:7524-52-9 ).SDS of cas: 7524-52-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7524-52-9) here.

The N-arylation of the side chain of histidine by using triarylbismuthines is reported. The reaction is promoted by copper(II) acetate in dichloromethane at 40°C under oxygen in the presence of diisopropylethylamine and 1,10-phenanthroline and allows the transfer of aryl groups with substituents at any position of the aromatic ring. The reaction shows excellent functional group tolerance and is applicable to dipeptides where the histidine is located at the N terminus. A histidine-guided backbone N-H arylation was observed in dipeptides where the histidine occupies the C terminus.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Quality Control of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Preparation and characterization of novel 4-bromo-3,4-dimethyl-1-phenyl-2-phospholene 1-oxide and the analogous phosphorus heterocycles or phospha sugars. Author is Yamada, Manabu; Yamashita, Mitsuji; Suyama, Takuya; Yamashita, Junko; Asai, Kazuhide; Niimi, Taishi; Ozaki, Nobuhisa; Fujie, Michio; Maddali, Kasthuraiah; Nakamura, Satoki; Ohnishi, Kazunori.

4-Bromo-3,4-dimethyl-1-phenyl-2-phospholene 1-oxide (3c) was 1st synthesized from 3,4-dimethyl-1-phenyl-2-phospholene 1-oxide (2c) by a bromo-radical substitution reaction occurred at C-4 position by N-bromosuccinimide and 2,2′-azobisisobutyronitrile. The novel phospha sugar analog 3c exerted high anti-proliferative effect on U937 cells evaluated by MTT in vitro methods and was much more efficient than that of Gleevec, which is known as a mol. targeting chemotherapeutical agent. The substitution of 2-phospholenes at C-3 and C-4 position with Me groups as well as 4-bromo substituent suggests a good anti-proliferative effect.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, is researched, Molecular C34H22NO2P, CAS is 1265884-98-7, about Iridium-catalyzed C3-selective asymmetric allylation of 7-azaindoles with secondary allylic alcohols, the main research direction is azaindole secondary allylic alc iridium catalyst allylation; aryl allyl pyrrolopyridine preparation enantioselective regioselective.Related Products of 1265884-98-7.

Iridium-catalyzed C3-selective asym. allylation of 7-azaindoles with racemic secondary allylic alcs. to give only branched allylation products in good to high yields with high enantioselectivity (up to >99.5% ee) was reported. Allylic alcs. and 7-azaindoles with a variety of functional groups including halogen and heteroaromatic groups were compatible with the reaction conditions. Furthermore, transformations of the obtained allylation products were demonstrated without a significant loss of enantiomeric excess.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem