Day: April 1, 2022

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Improved syntheses and characterization of the isomers of 3-methyl-1-phenylphospholene 1-oxide, the main research direction is phospholene oxide isomer; NMR phospholene oxide; IR phospholene oxide; Raman laser phospholene oxide; mass spectra phospholene oxide.Recommanded Product: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide.

Isomerically pure 3-methyl-1-phenyl-2-phospholene 1-oxide and 3-methyl-1-phenyl-3-phospholene 1-oxide were prepared and characterized by 1H (60 and 270 MHz), 31P and 13C NMR, IR, Laser Raman, and mass spectrometry. 1,4-Cycloaddition of isoprene and PhPCl2 after hydrolysis of the addition product, yielded a mixture of the above 2-isomer and small amounts of 3-isomer from which pure 2-isomer was separated by fractional crystallization The analog reaction with PhPBr2 gave isomerically pure 3-isomer. An improved and shortened work-up procedure for the phospholene oxides was used resulting in higher yields.

There is still a lot of research devoted to this compound(SMILES：CC1=CP(CC1)(C2=CC=CC=C2)=O)Recommanded Product: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, and with the development of science, more effects of this compound(707-61-9) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ) is researched.Recommanded Product: 2-Bromomethyl-1,3-dioxolane.Nedolya, N. A.; Tarasova, O. A.; Albanov, A. I.; Trofimov, B. A. published the article 《Synthesis and Unexpected Transformation of 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amine into 5-{[2-(2-Hydroxyethoxy)ethenyl]sulfanyl}-1H-pyrrol-2-amine in the Presence of a Superbase》 about this compound( cas:4360-63-8 ) in Russian Journal of Organic Chemistry. Keywords: ethenyloxyethyl diethyl hydroxyethoxy ethenylsulfanyl pyrrolamine preparation diastereoselective; dioxolanylmethylsulfanyl ethenyloxyethyl diethylpyrrolamine preparation one pot transformation potassium butoxide; diethylpropynamine ethenyloxyethyl isothiocyanate bromomethyl dioxolane cyclization potassium butoxide. Let’s learn more about this compound (cas:4360-63-8).

Successive one-pot reactions of monolithiated N,N-diethylprop-2-yn-1-amine with 2-(ethenyloxy)ethyl isothiocyanate and 2-(bromomethyl)-1,3-dioxolane afforded I in 91% yield. In the system t-BuOK-DMSO at room temperature (1 h), the product was converted to E/Z-II (yield 68%) instead of expected 1-vinyl derivative

There is still a lot of research devoted to this compound(SMILES：BrCC1OCCO1)Recommanded Product: 2-Bromomethyl-1,3-dioxolane, and with the development of science, more effects of this compound(4360-63-8) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Enantioselective Synthesis of 7(S)-Hydroxydocosahexaenoic Acid, a Possible Endogenous Ligand for PPARα.Category: dioxole.

We report the first total synthesis of the polyunsaturated fatty acid 7-hydroxydocosahexaenoic acid (7-HDHA) in racemic form and the enantioselective synthesis of 7-(S)-HDHA. Both syntheses follow a convergent approach that unites the C1-C9 and C10-C22 fragments using Sonogashira coupling and Boland reduction as key steps. These syntheses enabled the unambiguous characterization of this natural product for the first time and helped establish 7(S)-HDHA as a possible endogenous ligand for peroxisome proliferator-activated receptor alpha.

There is still a lot of research devoted to this compound(SMILES：BrCC1OCCO1)Category: dioxole, and with the development of science, more effects of this compound(4360-63-8) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application of 1265884-98-7. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine, is researched, Molecular C34H22NO2P, CAS is 1265884-98-7, about Iridium-Catalyzed Enantioselective Allylation of Aryl Enamides and Enecarbamates. Author is Yue, Bei-Bei; Deng, Yi; Zheng, Yu; Wei, Kun; Yang, Yu-Rong.

Aromatic enamide and enecarbamate as a novel type of nucleophile in the asym. allylation of branched, racemic allylic alcs. to give homoallylic ketones has been described. Enabled by Carreira’s chiral Ir (P, olefin) complex, the reactions proceed in good yields with excellent enantioselectivities.

There is still a lot of research devoted to this compound(SMILES：N1(P2OC3=CC=C4C=CC=CC4=C3C5=C6C=CC=CC6=CC=C5O2)C7=CC=CC=C7C=CC8=CC=CC=C81)Application of 1265884-98-7, and with the development of science, more effects of this compound(1265884-98-7) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

HPLC of Formula: 22353-34-0. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloropyridin-3-amine, is researched, Molecular C5H5ClN2, CAS is 22353-34-0, about First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-κB Activity As Novel Anticancer Agents. Author is Hamed, Mostafa M.; Darwish, Sarah S.; Herrmann, Jennifer; Abadi, Ashraf H.; Engel, Matthias.

The activation of the NF-κB transcription factor is a major adaptive response induced upon treatment with EGFR kinase inhibitors, leading to the emergence of resistance in nonsmall cell lung cancer and other tumor types. To suppress this survival mechanism, we developed new thiourea quinazoline derivatives that are dual inhibitors of both EGFR kinase and the NF-κB activity. Optimization of the hit compound, identified in a NF-κB reporter gene assay, led to compound 9b, exhibiting a cellular IC50 for NF-κB inhibition of 0.3 μM while retaining a potent EGFR kinase inhibition (IC50 = 60 nM). The dual inhibitors showed a higher potency than gefitinib to inhibit cell growth of EGFR-overexpressing tumor cell lines in vitro and in a xenograft model in vivo, while no signs of toxicity were observed An investigation of the mol. mechanism of NF-κB suppression revealed that the dual inhibitors depleted the transcriptional coactivator CREB-binding protein from the NF-κB complex in the nucleus.

There is still a lot of research devoted to this compound(SMILES：NC1=CC(=CN=C1)Cl)HPLC of Formula: 22353-34-0, and with the development of science, more effects of this compound(22353-34-0) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine( cas:1265884-98-7 ) is researched.Computed Properties of C34H22NO2P.Zhou, Yuan; Xiong, Tong; Zhou, Li-Yan; Li, Hong-Yan; Xiao, You-Cai; Chen, Fen-Er published the article 《Diastereo- and Enantioselective Synthesis of Borylated 3-Hydroxyoxindoles by Addition of gem-Diborylalkanes to Isatins》 about this compound( cas:1265884-98-7 ) in Organic Letters. Keywords: chiral hydroxyoxindole preparation reactivity stereoselective; crystal structure mol borylated hydroxyoxindole preparation; diastereoselective enantioselective stereoselective borylation hydroxyoxindole addition diborylalkane isatin. Let’s learn more about this compound (cas:1265884-98-7).

The catalytic asym. synthesis of borylated 3-hydroxyoxindoles by addition of gem-diborylalkanes to isatins is disclosed. Chiral 3-hydroxyoxindoles bearing two contiguous stereogenic centers were produced in up to >20:1 dr and 99% ee. The synthetic utility of the corresponding products is presented through several transformations of the boryl moiety. This report provides an efficient strategy to incorporate a boryl functional group toward the synthesis of 3-hydroxyoxindoles.

There is still a lot of research devoted to this compound(SMILES：N1(P2OC3=CC=C4C=CC=CC4=C3C5=C6C=CC=CC6=CC=C5O2)C7=CC=CC=C7C=CC8=CC=CC=C81)Computed Properties of C34H22NO2P, and with the development of science, more effects of this compound(1265884-98-7) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Wang, Haiqi; Song, Hongjian published an article about the compound: H-Trp-OMe.HCl( cas:7524-52-9,SMILESS:N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl ).Formula: C12H15ClN2O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:7524-52-9) through the article.

Previously, we reported for the first time that harmala alkaloids harmine and tetrahydroharmine exhibit activity against plant viruses, and we developed an analog, designated NK0209, that efficiently prevents and controls plant virus diseases. Here, to investigate the influence of the spatial configuration of NK0209 on its antiviral activities, we synthesized its four optical isomers, determined their configurations, and evaluated their activities against tobacco mosaic virus. All four isomers were significantly more active than ningnanmycin, which is one of the most successful com. antiviral agents, with in vivo inactivation, cure, and protection rates of 57.3±1.9%, 54.2±3.3%, 55.0±4.1% at 500μg/mL. Furthermore, anal. of structure-activity relationships demonstrated for the first time that the spatial conformation of NK0209 is an important determinant of its antiviral activity, and our results provide information about the possible optimum configuration for interaction of this mol. with its target protein.

There is still a lot of research devoted to this compound(SMILES：N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl)Formula: C12H15ClN2O2, and with the development of science, more effects of this compound(7524-52-9) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Development, characterization and pharmacological evaluation of amino acid prodrugs of (+)-Ibuprofen.Formula: C12H15ClN2O2.

The current research work investigate the neuronal pathway associated with NSAIDs that lead to the reduction in the initiation and progression of neurodegenerative diseases such as Alzheimer’s disease, Parkinsonism, etc. This research was developed amino acid prodrugs of the active enantiomer of ibuprofen, (+)-IBN and checks the pharmacol. effects, neuroprotective effect, anti inflammatory effect and anti-ulcerogenic effect. The treatment using (+)-IBN reduced the action of micoglia and the release of cytokine especially TNFα that are mainly involved in the neurodegenerative process. (+)- IBN reduced the deposition of soluble beta amyloid plaque by inhibiting the amyloid precursor protein, beta-secretase 1 and also enhancing the degradation process of beta amyloid via induction of insulin degrading enzyme. (+)-IBN also showed the property that the reduction in the TAU misfolding process. Therefore, the synthesized (+)-IBN amino acid prodrugs treatment effectively produce neuroprotective action, both restoring memory realed risk factors and reversing multiple brain neuropathol. hallmarks. The current research study developed the three amino acid prodrugs of (+)-ibuprofen by conjugating with L-Ph alanine, L-tryptophan and L-tyrosine also the physico-chem. characterization and spectral characterization was done. This study modify the carboxylic acid functional group present in the NSAIDs that lead to the formation of prodrugs with enhanced anti-inflammatory activity, reduced side effects and protective effect against neurodegenerative processes.

There is still a lot of research devoted to this compound(SMILES：N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl)Formula: C12H15ClN2O2, and with the development of science, more effects of this compound(7524-52-9) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

COA of Formula: C5H5ClN2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Chloropyridin-3-amine, is researched, Molecular C5H5ClN2, CAS is 22353-34-0, about The synthesis, structure-toxicity relationship of cisplatin derivatives for the mechanism research of cisplatin-induced nephrotoxicity.

Cisplatin is a widely used antineoplastic drug, while its nephrotoxicity limits the clin. application. Although several mechanisms contributing to nephrotoxicity are reported, the direct protein targets are unclear. Herein the authors reported the synthesis of 29 cisplatin derivatives and the structure-toxicity relation (STR) of these compounds with MTT assay in human renal proximal tubule cells (HK-2) and pig kidney epithelial cells (LLC-PK1). To the best of the authors’ knowledge, this study represented the 1st report regarding the structure-toxicity relation (STR) of cisplatin derivatives The potency of biotin-pyridine conjugated derivative 3 met the requirement for target identification, and the preliminary chem. proteomics results suggested that it is a promising tool for further target identification of cisplatin-induced nephrotoxicity.

There is still a lot of research devoted to this compound(SMILES：NC1=CC(=CN=C1)Cl)COA of Formula: C5H5ClN2, and with the development of science, more effects of this compound(22353-34-0) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Feng, Rui; Jie, Suyun; Braunstein, Pierre; Li, Bo-Geng published an article about the compound: 5-Chloropyridin-3-amine( cas:22353-34-0,SMILESS:NC1=CC(=CN=C1)Cl ).Name: 5-Chloropyridin-3-amine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:22353-34-0) through the article.

The ring-opening polymerization (ROP) of lactones is an effective method for the preparation of biocompatible and biodegradable aliphatic polyesters, for which the development of efficient organocatalysts with high activity and good controllability is highly desirable. A series of novel pyridyl-urea catalysts was synthesized and applied in the solvent-free ROP of lactones and trimethylene carbonate. Combined with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD), the pyridyl-urea/MTBD systems showed a fast and living/controlled behavior in the ROP, generating polymers with narrow mol. weight distributions. The influences of catalyst structure, type of base, pyridyl-urea/base ratio, feed ratio of monomer/initiator and reaction temperature on the catalytic properties were investigated. A possible mechanism was proposed on the basis of NMR titration and dilution experiments

There is still a lot of research devoted to this compound(SMILES：NC1=CC(=CN=C1)Cl)Name: 5-Chloropyridin-3-amine, and with the development of science, more effects of this compound(22353-34-0) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem