Day: August 26, 2021

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 2210-74-4, Name is 1-(2-Methoxyphenoxy)-2,3-epoxypropane, SMILES is COC1=C(OCC2CO2)C=CC=C1, belongs to dioxole compound. In a document, author is Wu, Liqiang, introduce the new discover, COA of Formula: https://www.ambeed.com/products/2210-74-4.html.

Benzo[d][1,3]dioxoles 1,4-thiazepines remarkable antitumor activities, benzo[d][1,3]dioxoles-fused 1,4thiazepines, which combine two biologically active heterocyclic cores, are expected to be of pharmacological interest, We therefore envisaged that integrating 1,4-thiazepine and benzo[d][1,3]dioxole moieties in one molecular platform could potentially produce novel compounds with significant synergistic antitumor properties. A series of novel benzo[d][1,3]dioxoles-fused 1,4-thiazepines, designed via molecular hybridization approach, were synthesized in very good yields using one-pot condensation of 3,4-methylenedioxyaniline, aldehydes, and alpha-mercaptocarboxylic acids under solvent-free condition. The anti-proliferative activities of all the synthesized compounds were assessed on two different human cancer cell lines (Esophageal squamous cell carcinoma Ec9706 and Eca109), and the results showed that compound 4e showed the best anti-tumor activity with IC50 values of 8.23 mu M and 16.22 mu M against Ec9706 and Eca109 cell lines, respectively, which was 2-3 times more potent than 5-Fluorouracil (IC50 = 23.26 mu M and 30.25 mu M against Ec9706 and Eca109 respectively). These novel benzo[d][1,3] dioxoles fused with bioactive heterocyclic skeletons may find their pharmaceutical applications after further investigations. (C) 2017 Elsevier Masson SAS. All rights reserved.

COA of Formula: https://www.ambeed.com/products/2210-74-4.html, This is the end of this tutorial post, and I hope it has helped your research about 2210-74-4.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 2210-74-4, Name is 1-(2-Methoxyphenoxy)-2,3-epoxypropane, SMILES is COC1=C(OCC2CO2)C=CC=C1, in an article , author is Hernandez, Paola, once mentioned of 2210-74-4, Reference of 2210-74-4.

Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis and additionally Leishmaniosis and Chagas disease affect approximately 30 million people. N-Acylhydrazone moiety is a repeated functional group present in several prototypes and drug candidates for these neglected diseases. On the other hand, furoxan system has been studied as pharmacophore for Leishmaniosis and Chagas diseases. Here we report on the design and preparation of forty hybrid furoxanyl N-acylhydrazones and on their activity on Mycobacterium tuberculosis, H37Rv and MDR strains, Trypanosoma cruzi, and Leishmania amazonensis. Among them, four derivatives displayed excellent to good selectivity indexes against the three different microorganisms. Hybrid compound N’-(4-phenyl-3-furoxanylmethylidene)isoniazide 9 showed the best antibacterial profile with MIC value 4.5 lesser than the value for the reference isoniazid against MDR strain. Furoxanyl N-acylhydrazone (E)-2-methyl-N’-(4-phenyl-3-furoxanylmethylidene)-4H-imidazo[1,2-a] pyridine-3-carbohydrazide 15 was ten-fold more potent against T cruzi Amastigotes than the standard drug nifurtimox. On the other hand, derivatives (E)-N’-(5-benzofuroxanylmethylidene)benzo[d][1,3] dioxole-5-carbohydrazide 25 and (E)-N’-(4-hydroxy-3-methoxyphenylmethylidene)-3-methylfuroxan-4-carbohydrazide 37 emerged as leads for the development of new leishmanicidal agents. The adequate stability, in simulated biological system and plasma, and the lack of mutagenicity of these derivatives allow us to propose them as candidates for further pre-clinical studies. (C) 2012 Elsevier Masson SAS. All rights reserved.

Interested yet? Read on for other articles about 2210-74-4, you can contact me at any time and look forward to more communication. Reference of 2210-74-4.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. 43157-50-2, Name is 2-Thioadenosine, SMILES is S=C1NC2=C(N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(N)=N1, in an article , author is Meuche-Albeny, J, once mentioned of 43157-50-2, Recommanded Product: 43157-50-2.

5-Chloromethyl-6-nitrobenzo[1,3]dioxole has been shown to react with 2-nitropropane anion to give C-alkylation by an S(RN)1 mechanism. The reaction was extended to various aliphatic, cyclic and heterocyclic nitronate anions, leading to a new series of nitrobenzo[1,3]dioxole derivatives.

Recommanded Product: 43157-50-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 43157-50-2 is helpful to your research.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. 28053-08-9, Name is Disodium UDP-glucose, SMILES is O[C@@H]1[C@@H](CO)O[C@@H]([C@@H]([C@H]1O)O)OP([O-])(OP([O-])(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)N3C=CC(NC3=O)=O)=O)=O.[Na+].[Na+], in an article , author is Manzetti, Sergio, once mentioned of 28053-08-9, Recommanded Product: Disodium UDP-glucose.

Molecular mutagens and carcinogens are structures which carry chemical and electronic properties that disturb and interact with the genomic machinery. Principally, a rule of thumb for carcinogens is that carcinogens are expected to introduce covalent irreversible bonding to one or several types of DNA bases, causing errors in the reading frame for the polymerases. 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid, better known as Aristolochic acid (AA1) is a recognized carcinogen which causes urotherial cancer and is found in certain plants. Its structure is particularly interesting given that it is closely related to phenanthrene in its polycyclic arrangement, and has four functional groups, a carboxyl-, a nitro-, a methoxy- and a dioxolane group. In this work, the structure of AA1 has been resolved at the MPWPW91 density functional theory method in combination with Aug-cc-pVDZ basis sets. A geometry analysis shows that in AA1 the carboxyl group’s torsion is caused by steric strain from the nitro group, which elevates the molecular plane of the first phenanthrene ring with 0.1 angstrom. The wavefunction analysis of AA1 shows that the ring deformation enhances a double -bond localization in the first ring, adjacent to the dioxalane group, and results in a decrease of ring aromaticity and induces a potentially frozen resonance. Intermolecular and intramolecular interactions were characterized by atoms in molecules and reduced density gradient analysis. This study brings novel information on the geometry and electronic structure of AA1, which are important for the further knowledge of its transformation in vivo and in situ. Copyright (c) 2013 John Wiley & Sons, Ltd.

Recommanded Product: Disodium UDP-glucose, Keep reading other articles of 28053-08-9! Don’t worry, you don’t need a PhD in chemistry to understand the explanations!

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. 106-91-2, Name is Oxiran-2-ylmethyl methacrylate, SMILES is CC(C(OCC1OC1)=O)=C, in an article , author is Wang, YZ, once mentioned of 106-91-2, Reference of 106-91-2.

Spectra of xenon-129 sorbed into two high permeability polymers are reported. The polymers are the copolymer of tetrafluoroethylene and 2,2-bis(trifluoromethyl)-4,5-difluoro-1,3-dioxole as well as poly(1-trimethylsilyl-1-propyne). At room temperature, the xenon-129 shifts are smaller than in conventional glassy polymers. The smaller xenon-129 shift indicates the presence of larger sorption sites in high permeability polymers relative to conventional polymers. The temperature dependence of solubility in these polymers is drastically different from the behavior in conventional polymers. There is a rapid exponential increase in solubility in high permeability polymers as temperature decreases corresponding to a large negative enthalpy change on sorption and it is this increase in solubility which leads to a large increase in shift with decreasing temperature. Pulse field gradient (PFG) determinations of the self-diffusion constant are made for xenon, propane, pentane and a decafluoropentane in the copolymer. Rapid diffusion is observed as well as a dependence of the apparent diffusion constant on the time scale of the PFG experiment. The translational mobility of smaller simpler moieties depends less on the time scale or equivalently, the length scale of observation in the PFG NMR experiment. For larger, more complex species, the interconnectedness of high free volume domains plays a role in reducing the apparent diffusion constant as the time of measurement increases. (C) 2002 Published by Elsevier Science Ltd.

If you’re interested in learning more about 106-91-2. The above is the message from the blog manager. Reference of 106-91-2.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. 67217-55-4, Name is Mono-(6-p-toluenesulfonyl)-β-cyclodextrin, SMILES is O=S(OC[C@@H]1[C@@]([C@@H]([C@H]([C@]([H])(O1)O[C@@]23[H])O)O)([H])O[C@]4([H])[C@H](O)[C@H]([C@@]([H])([C@H](O4)CO)O[C@]5([H])[C@H](O)[C@H]([C@@]([H])([C@H](O5)CO)O[C@]6([H])[C@H](O)[C@H]([C@@]([H])([C@H](O6)CO)O[C@@]([H])(O[C@@H]([C@]7(O[C@@]([H])(O[C@@H]([C@]8(O[C@]([H])([C@@H]([C@H]2O)O)O[C@@H]3CO)[H])CO)[C@@H]([C@H]8O)O)[H])CO)[C@@H]([C@H]7O)O)O)O)O)(C9=CC=C(C=C9)C)=O, in an article , author is Luginina, Jevgenija, once mentioned of 67217-55-4, SDS of cas: 67217-55-4.

The title compound, C13H21NO7 {systematic name: (3aR, 5S, 6R, 6aR)-5-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-6-(nitromethyl)tetrahydrofuro[2,3-d][1,3]dioxole}, consists of a substituted 2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxolane skeleton. The furanose ring A adopts a T-o(4) conformation. The fused dioxolane ring B and the substituent dioxolane ring C also have twisted conformations. There are no strong hydrogen bonds in the crystal structure: only weak C-H center dot center dot center dot O contacts are present, which link the molecules to form a three-dimensional structure.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 67217-55-4. SDS of cas: 67217-55-4.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. HPLC of Formula: https://www.ambeed.com/products/56786-63-1.html56786-63-1, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, SMILES is [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC([C@@]6(O)C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H])=O, belongs to dioxole compound. In a article, author is Ye, Yanping, introduce new discover of the category.

New drugs with enhanced electron donor properties that target the ryanodine receptor from skeletal muscle sarcoplasmic reticulum (RyR1) are shown to be potent inhibitors of single-channel activity. In this article, we synthesize derivatives of the channel activator 4-chloro-3-methyl phenol (4-CmC) and the 1,4-benzothiazepine channel inhibitor 4-[-3{1-(4-benzyl) piperidinyl}propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (K201, JTV519) with enhanced electron donor properties. Instead of activating channel activity (similar to 100 mu M), the 4-methoxy analog of 4-CmC [4-methoxy-3-methyl phenol (4-MmC)] inhibits channel activity at submicromolar concentrations (IC(50) = 0.34 +/- 0.08 mu M). Increasing the electron donor characteristics of K201 by synthesizing its dioxole congener results in an approximately 16 times more potent RyR1 inhibitor (IC(50) = 0.24 +/- 0.05 mu M) compared with K201 (IC(50) = 3.98 +/- 0.79 mu M). Inhibition is not caused by an increased closed time of the channel but seems to be caused by an open state block of RyR1. These alterations to chemical structure do not influence the ability of these drugs to affect Ca(2+)-dependent ATPase activity of sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase type 1. Moreover, the FKBP12 protein, which stabilizes RyR1 in a closed configuration, is shown to be a strong electron donor. It seems as if FKBP12, K201, its dioxole derivative, and 4-MmC inhibit RyR1 channel activity by virtue of their electron donor characteristics. These results embody strong evidence that designing new drugs to target RyR1 with enhanced electron donor characteristics results in more potent channel inhibitors. This is a novel approach to the design of new, more potent drugs with the aim of functionally modifying RyR1 single-channel activity.

You can also check out more blogs about 56786-63-1. HPLC of Formula: https://www.ambeed.com/products/56786-63-1.html.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. Product Details of 68515-73-168515-73-1, Name is (3R,4S,5S,6R)-2-(Decyloxy)-6-(hydroxymethyl)tetrahydro-2H-Pyran-3,4,5-triol, SMILES is O[C@H]1C(OCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O, belongs to dioxole compound. In a article, author is CORTEZ, E, introduce new discover of the category.

1,3-Dioxole, OCH2OCH=CH, has been synthesized and its far-infrared and low-frequency Raman spectra have been analyzed. The gas-phase far-infrared spectrum shows a series of eleven single-quantum-jump and three triple-quantum-jump transitions in the 40-330 cm-1 region. The low-frequency Raman spectrum exhibits eight ring-puckering transitions corresponding to DELTAupsilon = 2 or 4 transitions in the 160-300-cm-1 region. The ring-puckering potential energy function was determined to be V(cm-1) = (1.59 x 10(6))x4 – (4.18 x 10(4))x2, where x is the ring puckering coordinate in angstroms. This function indicates that the molecule is puckered with a barrier to planarity of 275 cm-1 and a bending angle of 24-degrees. The unexpected nonplanarity of 1,3-dioxole is attributed to the anomeric effect which can be present in molecules with O-C-O linkages. Molecular mechanics calculations utilizing the MM3 parametrization predict a planar structure for this molecule. However, the anomeric effect dictates that each of the =C-O-C-O torsional angles should have a strong desire to increase from 0-degrees toward 90-degrees in order to optimize n-sigma* overlap. When the MM3 force field is modified to reflect this by increasing the magnitude of the 2-fold torsional potential energy term V2 to -5.965 kcal/mol, a reasonably good agreement between the experimental and molecular mechanics potential functions can be obtained.

If you are hungry for even more, make sure to check my other article about 68515-73-1, Product Details of 68515-73-1.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. HPLC of Formula: https://www.ambeed.com/products/14618-80-5.html14618-80-5, Name is (R)-2-((Benzyloxy)methyl)oxirane, SMILES is [C@@H]1(COCC2=CC=CC=C2)OC1, belongs to dioxole compound. In a article, author is Kiskan, Fusun Seyma, introduce new discover of the category.

Catalytic reactions of alpha, beta-conjugated carbonyl compounds have been a practical tool towards the synthesis of different useful heterocyclic compounds. Despite the numerous reactions with carbon-carbon double bond conjugated carbonyls, reactions of acetylenic carbonyls are limited. In this study, efficient dioxole synthesis was carried out via acetylenic aldehydes and butadiene formation was preferred over cyclopropene formation via acetylenic esters as different functional groups on these substrates change the product distribution. Both reaction conditions (such as solvent and temperature) and electrophilic structure of metal carbenoids alter the product distribution; acceptor (A), donor-acceptor (DA), and acceptor-acceptor (AA) functionalized diazo compounds yield different product types over different mechanisms.

If you are hungry for even more, make sure to check my other article about 14618-80-5, HPLC of Formula: https://www.ambeed.com/products/14618-80-5.html.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. 29836-26-8, Name is Octyl β-D-glucopyranoside, SMILES is CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O, in an article , author is DAVIES, WJ, once mentioned of 29836-26-8, Synthetic Route of 29836-26-8.

Positron annihilation lifetime spectroscopy (PALS) and Doppler broadening spectroscopy (DBS) measurements are reported on poly (2,2-bis trifluoro 4,5 difluoro 1,3-dioxole) over the temperature range 303-423 K. The PALS data are best described by four components; the two longest lifetime components corresponding to ortho-positronium (o-Ps) annihilations with different characteristic lifetimes associated with different structural elements of the polymer. The total intensity attributed to o-Ps annihilations is small relative to that found in most common polymers. This suggests that in this material the free volume distribution is composed of a small number of large holes. The temperature dependence of the PALS data parallels that found in the DBS measurements. This type of free volume distribution is consistent with the high gas permeability found in these materials.

We very much hope you enjoy reading the articles and that you will join us to present your own research about 29836-26-8. Synthetic Route of 29836-26-8.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem